Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
"Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.
| Descriptor ID |
D008240
|
| MeSH Number(s) |
D08.811.682.690.708.660
|
| Concept/Terms |
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase- Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
- 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine
- 5-Dioxygenase Procollagen-Lysine, 2-Oxoglutarate
- Procollagen Lysine, 2 Oxoglutarate 5 Dioxygenase
- Lysine 2-Oxoglutarate Dioxygenase
- 2-Oxoglutarate Dioxygenase, Lysine
- Dioxygenase, Lysine 2-Oxoglutarate
- Lysine 2 Oxoglutarate Dioxygenase
- Lysyl Hydroxylase
- Hydroxylase, Lysyl
- Protocollagen Lysyl Hydroxylase
- Hydroxylase, Protocollagen Lysyl
- Collagen Lysyl Hydroxylase
- Hydroxylase, Collagen Lysyl
- Lysine Hydroxylase
- Hydroxylase, Lysine
|
Below are MeSH descriptors whose meaning is more general than "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase".
This graph shows the total number of publications written about "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase" by people in this website by year, and whether "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase" by people in Profiles.
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Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition. J Chem Inf Model. 2023 02 13; 63(3):986-1001.
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Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes. Sci Rep. 2022 08 22; 12(1):14256.
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Development of a High-Throughput Lysyl Hydroxylase (LH) Assay and Identification of Small-Molecule Inhibitors against LH2. SLAS Discov. 2019 04; 24(4):484-491.
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Phenotypic Consequences of PLOD2 Mutations in Bruck Syndrome Inform a Collagen Lysyl Hydroxylase Crystal Structure. J Bone Miner Res. 2018 07; 33(7):1376.
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Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding. Nat Commun. 2018 02 06; 9(1):512.
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FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch. Sci Rep. 2017 04 05; 7:46021.
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A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay. Arch Biochem Biophys. 2017 03 15; 618:45-51.
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Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space. J Biol Chem. 2016 Dec 09; 291(50):25799-25808.
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Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. Mol Cancer Res. 2016 Mar; 14(3):287-95.
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Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015 Mar 02; 125(3):1147-62.