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DONGYIN GUAN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Research 
    Collapse research activities and funding
    K01DK125602     (GUAN, DONGYIN)Aug 1, 2020 - May 31, 2025
    NIH
    Defining the role of non-clock genes in circadian physiology and pathophysiology
    Role: Principal Investigator
    F32DK116519     (GUAN, DONGYIN)Apr 1, 2018 - Mar 31, 2021
    NIH
    Mechanisms of high fat diet-induced circadian hepatic transcription and lipid metabolism reprogramming
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen Y, Liu P, Sabo A, Guan D. Human genetic variation determines 24-hour rhythmic gene expression and disease risk. Nat Commun. 2025 May 08; 16(1):4270. PMID: 40341583; PMCID: PMC12062405.
      Citations:    Fields:    Translation:HumansCells
    2. Li X, Liu C, Li W, Qi G, Dai Y, Gu C, Sun Y, Zhou W, Ciliberto VC, Liang J, Kumar S U, Guan D, Hu Z, Zheng H, Liu Z, Chen H, Wan YW, Sun Z. Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model. Alzheimers Dement. 2025 Mar; 21(3):e70024. PMID: 40156268; PMCID: PMC11953571.
      Citations:    Fields:    Translation:AnimalsCells
    3. Guan D, Chen Y, Liu P, Sabo A. Human genetic variation determines 24-hour rhythmic gene expression and disease risk. Res Sq. 2024 Aug 05. PMID: 39149455; PMCID: PMC11326361.
      Citations:    
    4. Li X, Liu C, Li W, Dai Y, Gu C, Zhou W, Ciliberto VC, Liang J, Udhaya KS, Guan D, Hu Z, Zheng H, Chen H, Liu Z, Wan YW, Sun Z. Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model. bioRxiv. 2024 May 05. PMID: 38746443; PMCID: PMC11092636.
      Citations:    
    5. Han Y, Xia G, Harris L, Liu P, Guan D, Wu Q. Reversal of Obesity by Enhancing Slow-wave Sleep via a Prokineticin Receptor Neural Circuit. bioRxiv. 2024 May 01. PMID: 38746393; PMCID: PMC11092673.
      Citations:    
    6. Mukhi D, Li L, Liu H, Doke T, Kolligundla LP, Ha E, Kloetzer K, Abedini A, Mukherjee S, Wu J, Dhillon P, Hu H, Guan D, Funai K, Uehara K, Titchenell PM, Baur JA, Wellen KE, Susztak K. ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules. J Clin Invest. 2023 Dec 05; 134(4). PMID: 38051585; PMCID: PMC10866669.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Zhu K, Celwyn IJ, Guan D, Xiao Y, Wang X, Hu W, Jiang C, Cheng L, Casellas R, Lazar MA. An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver. Mol Cell. 2023 10 05; 83(19):3457-3469.e7. PMID: 37802023; PMCID: PMC10575687.
      Citations: 5     Fields:    Translation:Animals
    8. Guan D, Bae H, Zhou D, Chen Y, Jiang C, La CM, Xiao Y, Zhu K, Hu W, Trinh TM, Liu P, Xiong Y, Cai B, Jang C, Lazar MA. Hepatocyte SREBP signaling mediates clock communication within the liver. J Clin Invest. 2023 04 17; 133(8). PMID: 37066875; PMCID: PMC10104893.
      Citations: 2     Fields:    Translation:Cells
    9. Xiao Y, Batmanov K, Hu W, Zhu K, Tom AY, Guan D, Jiang C, Cheng L, McCright SJ, Yang EC, Lanza MR, Liu Y, Hill DA, Lazar MA. Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. Sci Transl Med. 2023 02 08; 15(682):eadc9653. PMID: 36753562; PMCID: PMC10234568.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Jiang C, Liu P, La CM, Guan D. In silico integrative analysis of multi-omics reveals regulatory layers for diurnal gene expression in mouse liver. Front Endocrinol (Lausanne). 2022; 13:955070. PMID: 35937828; PMCID: PMC9353712.
      Citations:    
    11. Guan D, Lazar MA. Circadian Regulation of Gene Expression and Metabolism in the Liver. Semin Liver Dis. 2022 05; 42(2):113-121. PMID: 35263797; PMCID: PMC9806798.
      Citations:    Fields:    Translation:Humans
    12. Hu W, Jiang C, Kim M, Xiao Y, Richter HJ, Guan D, Zhu K, Krusen BM, Roberts AN, Miller J, Steger DJ, Lazar MA. Isoform-specific functions of PPAR? in gene regulation and metabolism. Genes Dev. 2022 03 01; 36(5-6):300-312. PMID: 35273075; PMCID: PMC8973844.
      Citations:    Fields:    Translation:AnimalsCells
    13. Guan D, Lazar MA. Interconnections between circadian clocks and metabolism. J Clin Invest. 2021 08 02; 131(15). PMID: 34338232; PMCID: PMC8321578.
      Citations: 6     Fields:    Translation:HumansAnimals
    14. Hu W, Jiang C, Kim M, Yang W, Zhu K, Guan D, Lv W, Xiao Y, Wilson JR, Rader DJ, Pui CH, Relling MV, Lazar MA. Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids. Cell Metab. 2021 08 03; 33(8):1592-1609.e7. PMID: 34233159; PMCID: PMC8340270.
      Citations: 4     Fields:    Translation:HumansCells
    15. Fang B, Guan D, Lazar MA. Using GRO-Seq to Measure Circadian Transcription and Discover Circadian Enhancers. Methods Mol Biol. 2021; 2130:127-148. PMID: 33284441; PMCID: PMC8073214.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz JD, Lazar MA. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science. 2020 09 11; 369(6509):1388-1394. PMID: 32732282; PMCID: PMC7849028.
      Citations: 30     Fields:    Translation:AnimalsCells
    17. Guan D, Lazar MA. Shining light on dark matter in the genome. Proc Natl Acad Sci U S A. 2019 12 10; 116(50):24919-24921. PMID: 31740615; PMCID: PMC6911184.
      Citations: 1     Fields:    Translation:Cells
    18. Hu W, Jiang C, Guan D, Dierickx P, Zhang R, Moscati A, Nadkarni GN, Steger DJ, Loos RJF, Hu C, Jia W, Soccio RE, Lazar MA. Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell Stem Cell. 2019 02 07; 24(2):299-308.e6. PMID: 30639037; PMCID: PMC6368460.
      Citations: 14     Fields:    Translation:HumansCells
    19. Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. 2018 08 09; 174(4):831-842.e12. PMID: 30057115; PMCID: PMC6086765.
      Citations: 59     Fields:    Translation:AnimalsCells
    20. Borck PC, Batista TM, Vettorazzi JF, Soares GM, Lubaczeuski C, Guan D, Boschero AC, Lazar MA, Carneiro EM, Vieira E. Nighttime light exposure enhances Rev-erba-targeting microRNAs and contributes to hepatic steatosis. Metabolism. 2018 08; 85:250-258. PMID: 29751019; PMCID: PMC6145802.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, Lazar MA. The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORa/?. Genes Dev. 2017 06 15; 31(12):1202-1211. PMID: 28747429; PMCID: PMC5558923.
      Citations: 23     Fields:    Translation:AnimalsCells
    22. Zhang Y, Fang B, Damle M, Guan D, Li Z, Kim YH, Gannon M, Lazar MA. HNF6 and Rev-erba integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms. Genes Dev. 2016 07 15; 30(14):1636-44. PMID: 27445394; PMCID: PMC4973293.
      Citations: 36     Fields:    Translation:AnimalsCells
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