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INNA ASTAPOVA

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tong W, Hannou SA, Sargsyan A, Zhang GF, Grimsrud PA, Astapova I, Herman MA. "Metformin Impairs Intestinal Fructose Metabolism". bioRxiv. 2023 May 15. PMID: 37131695; PMCID: PMC10153158.
      Citations:    
    2. Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R, Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA, Astapova I, Tsai LT, Herman MA. HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. JCI Insight. 2023 01 10; 8(1). PMID: 36413406; PMCID: PMC9870088.
      Citations: 4     Fields:    Translation:HumansAnimals
    3. Tong W, Hannou SA, Wang Y, Astapova I, Sargsyan A, Monn R, Thiriveedi V, Li D, McCann JR, Rawls JF, Roper J, Zhang GF, Herman MA. The intestine is a major contributor to circulating succinate in mice. FASEB J. 2022 10; 36(10):e22546. PMID: 36106538; PMCID: PMC9523828.
      Citations:    
    4. Doridot L, Hannou SA, Krawczyk SA, Tong W, Kim MS, McElroy GS, Fowler AJ, Astapova II, Herman MA. A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice. Nutrients. 2021 Oct 18; 13(10). PMID: 34684643; PMCID: PMC8540719.
      Citations:    Fields:    Translation:Animals
    5. Capozzi ME, Coch RW, Koech J, Astapova II, Wait JB, Encisco SE, Douros JD, El K, Finan B, Sloop KW, Herman MA, D'Alessio DA, Campbell JE. The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition. Diabetes. 2020 05; 69(5):882-892. PMID: 32005706; PMCID: PMC7171961.
      Citations: 14     Fields:    Translation:AnimalsCells
    6. Shimizu H, Lu Y, Vella KR, Damilano F, Astapova I, Amano I, Ritter M, Gallop MR, Rosenzweig AN, Cohen RN, Hollenberg AN. Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action. PLoS One. 2019; 14(8):e0220717. PMID: 31404087; PMCID: PMC6690520.
      Citations: 2     Fields:    Translation:Animals
    7. Freudenthal B, Shetty S, Butterfield NC, Logan JG, Han CR, Zhu X, Astapova I, Hollenberg AN, Cheng SY, Bassett JHD, Williams GR. Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha. Thyroid. 2019 05; 29(5):726-734. PMID: 30760120; PMCID: PMC6533791.
      Citations: 5     Fields:    Translation:Animals
    8. White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB. The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metab. 2018 Jun 05; 27(6):1281-1293.e7. PMID: 29779826; PMCID: PMC5990471.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    9. Bu P, Chen KY, Xiang K, Johnson C, Crown SB, Rakhilin N, Ai Y, Wang L, Xi R, Astapova I, Han Y, Li J, Barth BB, Lu M, Gao Z, Mines R, Zhang L, Herman M, Hsu D, Zhang GF, Shen X. Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metab. 2018 Jun 05; 27(6):1249-1262.e4. PMID: 29706565; PMCID: PMC5990465.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    10. Kim M, Astapova II, Flier SN, Hannou SA, Doridot L, Sargsyan A, Kou HH, Fowler AJ, Liang G, Herman MA. Intestinal, but not hepatic, ChREBP is required for fructose tolerance. JCI Insight. 2017 12 21; 2(24). PMID: 29263303; PMCID: PMC5752301.
      Citations: 34     Fields:    Translation:AnimalsCells
    11. Mendoza A, Astapova I, Shimizu H, Gallop MR, Al-Sowaimel L, MacGowan SMD, Bergmann T, Berg AH, Tenen DE, Jacobs C, Lyubetskaya A, Tsai L, Hollenberg AN. NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):E8458-E8467. PMID: 28923959; PMCID: PMC5635887.
      Citations: 9     Fields:    Translation:AnimalsCells
    12. Astapova I. Role of co-regulators in metabolic and transcriptional actions of thyroid hormone. J Mol Endocrinol. 2016 04; 56(3):73-97. PMID: 26673411.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    13. Serra M, Hawkins F, Rankin SA, Mori M, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Kotton DN, Kurmann AA, Astapova I, Hollenberg AN. Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell. 2015 Nov 05; 17(5):527-42. PMID: 26593959; PMCID: PMC4666682.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    14. Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Yen PM, Gauthier K. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016 Jan 01; 291(1):198-214. PMID: 26453307; PMCID: PMC4697156.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    15. Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN. NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015 Feb; 35(3):555-65. PMID: 25421714; PMCID: PMC4285426.
      Citations: 25     Fields:    Translation:AnimalsCells
    16. Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TR?1-governed pathway. J Clin Invest. 2014 May; 124(5):1976-86. PMID: 24713658; PMCID: PMC4001554.
      Citations: 15     Fields:    Translation:Animals
    17. Domouzoglou EM, Fisher FM, Astapova I, Fox EC, Kharitonenkov A, Flier JS, Hollenberg AN, Maratos-Flier E. Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. Endocrinology. 2014 May; 155(5):2031-40. PMID: 24564398; PMCID: PMC3990851.
      Citations: 12     Fields:    Translation:Animals
    18. Vella KR, Ramadoss P, Costa-E-Sousa RH, Astapova I, Ye FD, Holtz KA, Harris JC, Hollenberg AN. Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol. 2014 May; 34(9):1564-75. PMID: 24550004; PMCID: PMC3993596.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    19. Costa-e-Sousa RH, Astapova I, Ye F, Wondisford FE, Hollenberg AN. The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology. 2012 Oct; 153(10):5049-57. PMID: 22878400; PMCID: PMC3512014.
      Citations: 17     Fields:    Translation:AnimalsCells
    20. Astapova I, Hollenberg AN. The in vivo role of nuclear receptor corepressors in thyroid hormone action. Biochim Biophys Acta. 2013 Jul; 1830(7):3876-81. PMID: 22801336; PMCID: PMC3529203.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    21. Fozzatti L, Lu C, Kim DW, Park JW, Astapova I, Gavrilova O, Willingham MC, Hollenberg AN, Cheng SY. Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1). Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17462-7. PMID: 21987803; PMCID: PMC3198316.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    22. Astapova I, Vella KR, Ramadoss P, Holtz KA, Rodwin BA, Liao XH, Weiss RE, Rosenberg MA, Rosenzweig A, Hollenberg AN. The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol. 2011 Feb; 25(2):212-24. PMID: 21239618; PMCID: PMC3386544.
      Citations: 44     Fields:    Translation:Animals
    23. Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS, Hollenberg AN, Maratos-Flier E. Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem. 2010 May 07; 285(19):14078-82. PMID: 20236931; PMCID: PMC2863226.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    24. Astapova I, Dordek MF, Hollenberg AN. The thyroid hormone receptor recruits NCoR via widely spaced receptor-interacting domains. Mol Cell Endocrinol. 2009 Aug 13; 307(1-2):83-8. PMID: 19524130.
      Citations: 9     Fields:    Translation:HumansCells
    25. Astapova I, Lee LJ, Morales C, Tauber S, Bilban M, Hollenberg AN. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19544-9. PMID: 19052228; PMCID: PMC2614797.
      Citations: 85     Fields:    Translation:AnimalsCells
    26. Hodgson MC, Astapova I, Hollenberg AN, Balk SP. Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors. Cancer Res. 2007 Sep 01; 67(17):8388-95. PMID: 17804755.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    27. Blumberg JM, Tzameli I, Astapova I, Lam FS, Flier JS, Hollenberg AN. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem. 2006 Apr 21; 281(16):11205-13. PMID: 16467308.
      Citations: 71     Fields:    Translation:AnimalsCells
    28. Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, Balk SP, Hollenberg AN. The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. J Biol Chem. 2005 Feb 25; 280(8):6511-9. PMID: 15598662.
      Citations: 61     Fields:    Translation:HumansCells
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