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MARK HERMAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address7200 CAMBRIDGE
ORCID ORCID Icon0000-0001-6979-103X Additional info
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Research 
    Collapse research activities and funding
    R01DK121710     (HERMAN, MARK A;NEWGARD, CHRISTOPHER B)Aug 19, 2019 - Jul 31, 2023
    NIH
    Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease
    Role: Principal Investigator
    R01DK100425     (HERMAN, MARK A)Jan 15, 2014 - Feb 28, 2025
    NIH
    The Role of ChREBP in Fructose Induced Metabolic Disease
    Role: Principal Investigator
    K08DK076726     (HERMAN, MARK A)Sep 20, 2006 - Jun 30, 2011
    NIH
    Adipose Tissue Branched-Chain Amino Acid Metabolism and Glucose Homeostasis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An J, Astapova I, Zhang G, Cangelosi AL, Ilkayeva O, Marchuk H, Muehlbauer MJ, George T, Brozinick J, Herman MA, Newgard CB. Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor in energy metabolism. bioRxiv. 2024 Sep 21. PMID: 39345566; PMCID: PMC11429843.
      Citations:    
    2. Tong W, Hannou SA, Sargsyan A, Zhang GF, Grimsrud PA, Astapova I, Herman MA. "Metformin Impairs Intestinal Fructose Metabolism". bioRxiv. 2023 May 15. PMID: 37131695; PMCID: PMC10153158.
      Citations:    
    3. Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R, Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA, Astapova I, Tsai LT, Herman MA. HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. JCI Insight. 2023 01 10; 8(1). PMID: 36413406; PMCID: PMC9870088.
      Citations: 4     Fields:    Translation:HumansAnimals
    4. Wang L, Tang Y, Herman MA, Spurney RF. Pharmacologic blockade of the natriuretic peptide clearance receptor promotes weight loss and enhances insulin sensitivity in type 2 diabetes. Transl Res. 2023 05; 255:140-151. PMID: 36563959; PMCID: PMC10441142.
      Citations: 1     Fields:    Translation:Animals
    5. Tong W, Hannou SA, Wang Y, Astapova I, Sargsyan A, Monn R, Thiriveedi V, Li D, McCann JR, Rawls JF, Roper J, Zhang GF, Herman MA. The intestine is a major contributor to circulating succinate in mice. FASEB J. 2022 10; 36(10):e22546. PMID: 36106538; PMCID: PMC9523828.
      Citations:    
    6. Yenilmez B, Kelly M, Zhang GF, Wetoska N, Ilkayeva OR, Min K, Rowland L, DiMarzio C, He W, Raymond N, Lifshitz L, Pan M, Han X, Xie J, Friedline RH, Kim JK, Gao G, Herman MA, Newgard CB, Czech MP. Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice. J Biol Chem. 2022 10; 298(10):102401. PMID: 35988648; PMCID: PMC9490592.
      Citations:    
    7. Haslam DE, Chasman DI, Peloso GM, Herman MA, Dupuis J, Lichtenstein AH, Smith CE, Ridker PM, Jacques PF, Mora S, McKeown NM. Sugar-Sweetened Beverage Consumption and Plasma Lipoprotein Cholesterol, Apolipoprotein, and Lipoprotein Particle Size Concentrations in US Adults. J Nutr. 2022 11; 152(11):2534-2545. PMID: 36774119; PMCID: PMC9644170.
      Citations: 1     Fields:    Translation:Humans
    8. Haslam DE, Chasman DI, Peloso GM, Herman MA, Lichtenstein AH, Smith CE, Ridker PM, Jacques PF, Mora S, McKeown NM, Dupuis J. Sugar-sweetened Beverage Consumption and Plasma Lipoprotein Cholesterol, Apolipoprotein, and Lipoprotein Particle Size Concentrations in U.S. Adults. J Nutr. 2022 Aug 02. PMID: 35918259; PMCID: PMC9644170.
      Citations:    
    9. Katz LS, Brill G, Zhang P, Kumar A, Baumel-Alterzon S, Honig LB, Karakose E, Tanase M, Alvarsson A, Davenport B, Wang P, Lambertini L, Stanley SA, Homann D, Stewart AF, Lo JC, Herman MA, Scott DK, G?mez-Banoy N, Doridot L, Garcia-Oca?a A. Maladaptive positive feedback production of ChREBP? underlies glucotoxic ?-cell failure. Nat Commun. 2022 07 30; 13(1):4423. PMID: 35908073; PMCID: PMC9339008.
      Citations:    
    10. Doridot L, Hannou SA, Krawczyk SA, Tong W, Kim MS, McElroy GS, Fowler AJ, Astapova II, Herman MA. A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice. Nutrients. 2021 Oct 18; 13(10). PMID: 34684643; PMCID: PMC8540719.
      Citations:    Fields:    Translation:Animals
    11. Herman MA, Birnbaum MJ. Molecular aspects of fructose metabolism and metabolic disease. Cell Metab. 2021 12 07; 33(12):2329-2354. PMID: 34619074; PMCID: PMC8665132.
      Citations: 8     Fields:    Translation:Humans
    12. Haslam DE, Peloso GM, Guirette M, Imamura F, Bartz TM, Pitsillides AN, Wang CA, Li-Gao R, Westra JM, Young KL, Graff M, Wood AC, Braun KVE, Luan J, Kiefte-de Jong JC, Ghanbari M, Tintle N, Lemaitre RN, Mook-Kanamori DO, North K, Helminen M, Mossavar-Rahmani Y, Snetselaar L, Martin LW, Viikari JS, Oddy WH, Pennell CE, Rosendall FR, Ikram MA, Uitterlinden AG, Psaty BM, Mozaffarian D, Rotter JI, Taylor KD, Raitakari OT, Livingston KA, Voortman T, Forouhi NG, Wareham NJ, Rich SS, Manson JE, Mora S, Ridker PM, Merino J, Meigs JB, Dashti HS, Chasman DI, Lichtenstein AH, Smith CE, Herman MA, McKeown NM, Pitk?nen N, K?h?nen M, Lehtim?ki T, de Mutsert R, Dupuis J. Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations. Circ Genom Precis Med. 2021 08; 14(4):e003288. PMID: 34270325; PMCID: PMC8373451.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    13. White PJ, McGarrah RW, Herman MA, Bain JR, Shah SH, Newgard CB. Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street. Mol Metab. 2021 10; 52:101261. PMID: 34044180; PMCID: PMC8513145.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    14. Katz LS, Baumel-Alterzon S, Scott DK, Herman MA. Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets. J Biol Chem. 2021 Jan-Jun; 296:100623. PMID: 33812993; PMCID: PMC8102921.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    15. Herman MA. Metabolic liver disease - what's in a name? Nat Rev Endocrinol. 2021 02; 17(2):79-80. PMID: 33257823.
      Citations: 1     Fields:    Translation:HumansCells
    16. Ezaz G, Trivedi HD, Filozof C, Howard K, L Parrish M, Kim M, Herman MA, Nasser I, Afdhal NH, Jiang ZG, Lai M, Connelly MA. Differential Associations of Circulating MicroRNAs With Pathogenic Factors in NAFLD. Hepatol Commun. 2020 May; 4(5):670-680. PMID: 32363318; PMCID: PMC7193128.
      Citations: 5     Fields:    
    17. Haslam DE, Peloso GM, Herman MA, Lichtenstein AH, Smith CE, McKeown NM, Dupuis J. Beverage Consumption and Longitudinal Changes in Lipoprotein Concentrations and Incident Dyslipidemia in US Adults: The Framingham Heart Study. J Am Heart Assoc. 2020 03 03; 9(5):e014083. PMID: 32098600; PMCID: PMC7335580.
      Citations: 11     Fields:    Translation:Humans
    18. Capozzi ME, Coch RW, Koech J, Astapova II, Wait JB, Encisco SE, Douros JD, El K, Finan B, Sloop KW, Herman MA, D'Alessio DA, Campbell JE. The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition. Diabetes. 2020 05; 69(5):882-892. PMID: 32005706; PMCID: PMC7171961.
      Citations: 14     Fields:    Translation:AnimalsCells
    19. Herman MA, Campbell JE, D'Alessio DA. One small step for mice, one giant leap for GWAS? J Clin Invest. 2019 10 01; 129(10):4083-4085. PMID: 31498152; PMCID: PMC6763235.
      Citations:    Fields:    Translation:HumansAnimals
    20. Sargsyan A, Herman MA. Regulation of Glucose Production in the Pathogenesis of Type 2 Diabetes. Curr Diab Rep. 2019 08 03; 19(9):77. PMID: 31377934; PMCID: PMC6834297.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    21. Sandhu B, Perez Matos MC, Tran S, Zhong A, Csizmadia E, Kim M, Herman MA, Nasser I, Lai M, Jiang ZG. Quantitative digital pathology reveals association of cell-specific PNPLA3 transcription with NAFLD disease activity. JHEP Rep. 2019 Sep; 1(3):199-202. PMID: 32039370; PMCID: PMC7001539.
      Citations: 3     
    22. Douros JD, Niu J, Sdao S, Gregg T, Fisher-Wellman K, Bharadwaj M, Molina A, Arumugam R, Martin M, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell J, D'Alessio D. Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight. 2019 03 21; 4(6). PMID: 30777938; PMCID: PMC6483064.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    23. Danford CJ, Connelly MA, Shalaurova I, Kim M, Herman MA, Nasser I, Otvos JD, Afdhal NH, Jiang ZG, Lai M. A Pathophysiologic Approach Combining Genetics and Insulin Resistance to Predict the Severity of Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2018 Dec; 2(12):1467-1478. PMID: 30556036; PMCID: PMC6287585.
      Citations: 6     Fields:    
    24. White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB. The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metab. 2018 Jun 05; 27(6):1281-1293.e7. PMID: 29779826; PMCID: PMC5990471.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    25. Kumar A, Katz LS, Schulz AM, Kim M, Honig LB, Li L, Davenport B, Homann D, Herman MA, Haynes CM, Chipuk JE, Scott DK, Garcia-Oca?a A. Activation of Nrf2 Is Required for Normal and ChREBPa-Augmented Glucose-Stimulated ?-Cell Proliferation. Diabetes. 2018 08; 67(8):1561-1575. PMID: 29764859; PMCID: PMC6054434.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    26. Jiang ZG, Tapper EB, Kim M, Connelly MA, Krawczyk SA, Yee EU, Herman MA, Mukamal KJ, Lai M. Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease. J Clin Gastroenterol. 2018 May/Jun; 52(5):444-451. PMID: 28362682; PMCID: PMC5623166.
      Citations: 4     Fields:    Translation:Humans
    27. Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA, MetGen Investigators, ACCORD/ACCORDion Investigators. Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1428-1440. PMID: 29650774; PMCID: PMC6014560.
      Citations: 14     Fields:    Translation:Humans
    28. Hannou SA, Haslam DE, McKeown NM, Herman MA. Fructose metabolism and metabolic disease. J Clin Invest. 2018 02 01; 128(2):545-555. PMID: 29388924; PMCID: PMC5785258.
      Citations: 117     Fields:    Translation:HumansAnimals
    29. Haslam DE, McKeown NM, Herman MA, Lichtenstein AH, Dashti HS. Interactions between Genetics and Sugar-Sweetened Beverage Consumption on Health Outcomes: A Review of Gene-Diet Interaction Studies. Front Endocrinol (Lausanne). 2017; 8:368. PMID: 29375475; PMCID: PMC5767076.
      Citations: 8     Fields:    
    30. Kim M, Astapova II, Flier SN, Hannou SA, Doridot L, Sargsyan A, Kou HH, Fowler AJ, Liang G, Herman MA. Intestinal, but not hepatic, ChREBP is required for fructose tolerance. JCI Insight. 2017 12 21; 2(24). PMID: 29263303; PMCID: PMC5752301.
      Citations: 34     Fields:    Translation:AnimalsCells
    31. McKeown NM, Dashti HS, Ma J, Haslam DE, Kiefte-de Jong JC, Smith CE, Tanaka T, Graff M, Lemaitre RN, Rybin D, Frazier-Wood AC, Mook-Kanamori DO, Li Y, Wang CA, Leermakers ETM, Young KL, Mukamal KJ, Cupples LA, Chen TA, Li-Gao R, Huang T, Oddy WH, Raitakari O, Rice K, Meigs JB, Steffen LM, Rosendaal FR, Hofman A, Psaty BM, Uitterlinden AG, Viikari J, Siscovick DS, North KE, Mozaffarian D, Rich SS, Qi L, Pennell CE, Franco OH, Herman MA, Sonestedt E, Mikkil? V, Schulz CA, Ericson U, K?h?nen M, Brunkwall L, Sepp?l? I, Dupuis J, Orho-Melander M, de Mutsert R, Lehtim?ki T. Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis. Diabetologia. 2018 02; 61(2):317-330. PMID: 29098321; PMCID: PMC5826559.
      Citations: 10     Fields:    Translation:Humans
    32. Ter Horst KW, Gilijamse PW, Demirkiran A, van Wagensveld BA, Ackermans MT, Verheij J, Romijn JA, Nieuwdorp M, Maratos-Flier E, Herman MA, Serlie MJ. The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans. Mol Metab. 2017 11; 6(11):1493-1502. PMID: 29107295; PMCID: PMC5681276.
      Citations: 15     Fields:    Translation:Humans
    33. Fisher FM, Kim M, Doridot L, Cunniff JC, Parker TS, Levine DM, Hellerstein MK, Hudgins LC, Maratos-Flier E, Herman MA. A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. Mol Metab. 2017 01; 6(1):14-21. PMID: 28123933; PMCID: PMC5220398.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    34. Kim MS, Krawczyk SA, Doridot L, Fowler AJ, Wang JX, Trauger SA, Noh HL, Kang HJ, Meissen JK, Blatnik M, Kim JK, Lai M, Herman MA. ChREBP regulates fructose-induced glucose production independently of insulin signaling. J Clin Invest. 2016 11 01; 126(11):4372-4386. PMID: 27669460; PMCID: PMC5096918.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    35. Herman MA, Samuel VT. The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends Endocrinol Metab. 2016 10; 27(10):719-730. PMID: 27387598; PMCID: PMC5035631.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    36. Jiang ZG, Tapper EB, Pimentel CF, Kim M, Krawczyk S, Afdhal N, Robson SC, Herman MA, Mukamal KJ, Lai M, Connelly MA, Feldbr?gge L, Otvos JD. Steatohepatitis and liver fibrosis are predicted by the characteristics of very low density lipoprotein in nonalcoholic fatty liver disease. Liver Int. 2016 08; 36(8):1213-20. PMID: 26815314; PMCID: PMC4942367.
      Citations: 15     Fields:    Translation:Humans
    37. Herman MA, Rosen ED. Making Biological Sense of GWAS Data: Lessons from the FTO Locus. Cell Metab. 2015 Oct 06; 22(4):538-9. PMID: 26445508.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    38. Zhang P, Kumar A, Katz LS, Li L, Paulynice M, Herman MA, Scott DK. Induction of the ChREBP? Isoform Is Essential for Glucose-Stimulated ?-Cell Proliferation. Diabetes. 2015 Dec; 64(12):4158-70. PMID: 26384380; PMCID: PMC4657577.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    39. Poon W, Lyssenko V, Groop L, Nichols B, Wilmot M, Robson S, Enjyoji K, Herman MA, Hu C, Zhang R, Jia W, Ma R, Florez JC, Friedman DJ, Todd JN. Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans. J Clin Endocrinol Metab. 2015 May; 100(5):E688-96. PMID: 25719930; PMCID: PMC4422893.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    40. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. PMID: 25303528; PMCID: PMC4260972.
      Citations: 269     Fields:    Translation:HumansAnimalsCells
    41. Dushay JR, Toschi E, Mitten EK, Fisher FM, Herman MA, Maratos-Flier E. Fructose ingestion acutely stimulates circulating FGF21 levels in humans. Mol Metab. 2015 Jan; 4(1):51-7. PMID: 25685689; PMCID: PMC4314524.
      Citations: 95     Fields:    
    42. Herman MA, Peroni OD, Villoria J, Abumrad NA, Klein S, Kahn BB, Sch?n MR, Bl?her M. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 2012 Apr 19; 484(7394):333-8. PMID: 22466288; PMCID: PMC3341994.
      Citations: 262     Fields:    Translation:HumansAnimalsCells
    43. Speakman JR, Arch JR, Auwerx J, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E, Tsch?p MH, Br?ning JC, M?ller TD, M?nzberg H. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9(1):57-63. PMID: 22205519; PMCID: PMC3654855.
      Citations: 366     Fields:    Translation:Animals
    44. Canto C, Yamamoto H, Yu J, Herman MA, Mataki C, Kahn BB, Auwerx J, Noriega LG, Feige JN. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep. 2011 Sep 30; 12(10):1069-76. PMID: 21836635; PMCID: PMC3185337.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    45. Kraus D, Herman MA, Kahn BB. Leveraging leptin for type I diabetes? Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4793-4. PMID: 20212134; PMCID: PMC2841872.
      Citations: 8     Fields:    Translation:HumansAnimals
    46. Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem. 2010 Apr 09; 285(15):11348-56. PMID: 20093359; PMCID: PMC2857013.
      Citations: 154     Fields:    Translation:Animals
    47. Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest. 2006 Jul; 116(7):1767-75. PMID: 16823474; PMCID: PMC1483149.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
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