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SUNDARARAJAH THEVANANTHER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    R01DK069558     (THEVANANTHER, SUNDARARAJAH)May 1, 2006 - Mar 31, 2012
    NIH
    Purinergic Regulation of hepatocyte proliferation
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ambati CSR, Arunachalam AR, Samuel SS, Mani A, Maynard JP, Stayer KM, Dybbro E, Narayanan S, Biswas A, Pathan S, Soni K, Kamal AHM, Putluri N, Desai MS, Thevananther S. P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality. Am J Physiol Gastrointest Liver Physiol. 2023 11 01; 325(5):G471-G491. PMID: 37697947; PMCID: PMC10812707.
      Citations:    Fields:    Translation:Animals
    2. Shneider BL, Cortes-Santiago N, Schady DA, Krishnamoorthy S, Thevananther S, Rajapakshe K, Perera D, Huang S, Coarfa C. Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer. Am J Physiol Gastrointest Liver Physiol. 2021 03 01; 320(3):G366-G379. PMID: 33470189; PMCID: PMC8202241.
      Citations:    Fields:    Translation:AnimalsCells
    3. Eblimit Z, Thevananther S, Karpen SJ, Taegtmeyer H, Moore DD, Adorini L, Penny DJ, Desai MS. TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice. Cardiovasc Ther. 2018 Oct; 36(5):e12462. PMID: 30070769; PMCID: PMC6800140.
      Citations: 16     Fields:    Translation:AnimalsCells
    4. Maynard JP, Lee JS, Sohn BH, Yu X, Lopez-Terrada D, Finegold MJ, Goss JA, Thevananther S. P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients. Oncotarget. 2015 Dec 01; 6(38):41162-79. PMID: 26517690; PMCID: PMC4747397.
      Citations: 16     Fields:    Translation:HumansCells
    5. Fleet T, Zhang B, Lin F, Zhu B, Dasgupta S, Stashi E, Tackett B, Thevananther S, Rajapakshe KI, Gonzales N, Dean A, Mao J, Timchenko N, Malovannaya A, Qin J, Coarfa C, DeMayo F, Dacso CC, Foulds CE, O'Malley BW, York B. SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):E6068-77. PMID: 26487680; PMCID: PMC4640775.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Tackett BC, Sun H, Mei Y, Maynard JP, Cheruvu S, Mani A, Hernandez-Garcia A, Vigneswaran N, Karpen SJ, Thevananther S. P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy. Am J Physiol Gastrointest Liver Physiol. 2014 Dec 01; 307(11):G1073-87. PMID: 25301185; PMCID: PMC4254960.
      Citations: 20     Fields:    Translation:AnimalsCells
    7. Sen P, Dharmadhikari AV, Majewski T, Mohammad MA, Kalin TV, Zabielska J, Ren X, Bray M, Brown HM, Welty S, Thevananther S, Langston C, Szafranski P, Justice MJ, Kalinichenko VV, Gambin A, Belmont J, Stankiewicz P. Comparative analyses of lung transcriptomes in patients with alveolar capillary dysplasia with misalignment of pulmonary veins and in foxf1 heterozygous knockout mice. PLoS One. 2014; 9(4):e94390. PMID: 24722050; PMCID: PMC3983164.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    8. Desai MS, Eblimit Z, Thevananther S, Kosters A, Moore DD, Penny DJ, Karpen SJ. Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis. Liver Int. 2015 Apr; 35(4):1464-77. PMID: 24330504; PMCID: PMC4057995.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Kohjima M, Tsai TH, Tackett BC, Thevananther S, Li L, Chang BH, Chan L. Delayed liver regeneration after partial hepatectomy in adipose differentiation related protein-null mice. J Hepatol. 2013 Dec; 59(6):1246-54. PMID: 23928401; PMCID: PMC4001732.
      Citations: 13     Fields:    Translation:AnimalsCells
    10. Whittenton J, Pitchumani R, Thevananther S, Mohanty K. Evaluation of asymmetric immunoliposomal nanoparticles for cellular uptake. J Microencapsul. 2013; 30(1):55-63. PMID: 22742513; PMCID: PMC3661217.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Mei Y, Thevananther S. Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice. Hepatology. 2011 Nov; 54(5):1777-89. PMID: 21748771; PMCID: PMC3579770.
      Citations: 24     Fields:    Translation:AnimalsCells
    12. Thevananther S. Adipose to the rescue: peripheral fat fuels liver regeneration. Hepatology. 2010 Dec; 52(6):1875-6. PMID: 21105105.
      Citations: 6     Fields:    Translation:Animals
    13. Desai MS, Shabier Z, Taylor M, Lam F, Thevananther S, Kosters A, Karpen SJ. Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis. Hepatology. 2010 Jun; 51(6):2097-107. PMID: 20512997; PMCID: PMC3678910.
      Citations: 29     Fields:    Translation:AnimalsCells
    14. Gonzales E, Julien B, Nicou A, Doignon I, Lagoudakis L, Garcin I, Azoulay D, Castaing D, Samuel D, Hernandez-Garcia A, Awad SS, Combettes L, Thevananther S, Tordjmann T, Serri?re-Lanneau V, Duclos-Vall?e JC. ATP release after partial hepatectomy regulates liver regeneration in the rat. J Hepatol. 2010 Jan; 52(1):54-62. PMID: 19914731; PMCID: PMC3625734.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    15. Kosters A, White DD, Sun H, Thevananther S, Karpen SJ. Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid X receptor alpha. J Hepatol. 2009 Nov; 51(5):898-908. PMID: 19767119; PMCID: PMC2818213.
      Citations: 12     Fields:    Translation:AnimalsCells
    16. Pizarro M, Solis N, Sun H, Thevananther S, Arrese M, Arab JP. Mild hypothermia does not affect liver regeneration after partial hepatectomy in mice. Liver Int. 2009 Mar; 29(3):344-8. PMID: 18662277; PMCID: PMC2859296.
      Citations: 2     Fields:    Translation:Animals
    17. Whittenton J, Harendra S, Pitchumani R, Mohanty K, Vipulanandan C, Thevananther S. Evaluation of asymmetric liposomal nanoparticles for encapsulation of polynucleotides. Langmuir. 2008 Aug 19; 24(16):8533-40. PMID: 18597508.
      Citations: 6     Fields:    
    18. Ghose R, Mulder J, von Furstenberg RJ, Thevananther S, Kuipers F, Karpen SJ. Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver. J Hepatol. 2007 Jan; 46(1):115-23. PMID: 17107731; PMCID: PMC1847570.
      Citations: 17     Fields:    Translation:AnimalsCells
    19. Zimmerman TL, Thevananther S, Ghose R, Burns AR, Karpen SJ. Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J Biol Chem. 2006 Jun 02; 281(22):15434-40. PMID: 16551633.
      Citations: 48     Fields:    Translation:HumansCells
    20. Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept. 2004 Aug 16; 2(1):4. PMID: 15312234; PMCID: PMC514570.
      Citations: 62     
    21. Thevananther S, Karpen SJ. Calcium is good for the nucleus. J Hepatol. 2004 Apr; 40(4):720-2. PMID: 15030997.
      Citations:    Fields:    
    22. Thevananther S, Sun H, Li D, Arjunan V, Awad SS, Wyllie S, Zimmerman TL, Goss JA, Karpen SJ. Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes. Hepatology. 2004 Feb; 39(2):393-402. PMID: 14767992.
      Citations: 46     Fields:    Translation:AnimalsCells
    23. Li D, Zimmerman TL, Thevananther S, Lee HY, Kurie JM, Karpen SJ. Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. J Biol Chem. 2002 Aug 30; 277(35):31416-22. PMID: 12105223.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    24. Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2002 Jun; 2(6):721-31. PMID: 12062085.
      Citations: 185     Fields:    Translation:AnimalsCells
    25. Thevananther S, Rivera A, Rivkees SA. A1 adenosine receptor activation inhibits neurite process formation by Rho kinase-mediated pathways. Neuroreport. 2001 Oct 08; 12(14):3057-63. PMID: 11568636.
      Citations: 12     Fields:    Translation:AnimalsCells
    26. Rivkees SA, Thevananther S, Hao H. Are A3 adenosine receptors expressed in the brain? Neuroreport. 2000 Apr 07; 11(5):1025-30. PMID: 10790877.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    27. Xu G, Shneider BL, Shefer S, Nguyen LB, Batta AK, Tint GS, Arrese M, Thevananther S, Ma L, Stengelin S, Kramer W, Greenblatt D, Pcolinsky M, Salen G. Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits. J Lipid Res. 2000 Feb; 41(2):298-304. PMID: 10681414.
      Citations: 14     Fields:    Translation:AnimalsCells
    28. Sangan P, Thevananther S, Sangan S, Rajendran VM, Binder HJ. Colonic H-K-ATPase alpha- and beta-subunits express ouabain-insensitive H-K-ATPase. Am J Physiol Cell Physiol. 2000 Jan; 278(1):C182-9. PMID: 10644526.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    29. Feldenberg LR, Thevananther S, del Rio M, de Leon M, Devarajan P. Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells. Am J Physiol. 1999 06; 276(6):F837-46. PMID: 10362772.
      Citations: 37     Fields:    Translation:AnimalsCells
    30. Thevananther S, Brecher AS. Isolation of angiotensin converting enzyme (ACE) binding protein from human serum with an ACE affinity column. Can J Physiol Pharmacol. 1999 Mar; 77(3):216-23. PMID: 10535696.
      Citations: 7     Fields:    Translation:HumansAnimals
    31. Sun AQ, Ananthanarayanan M, Soroka CJ, Thevananther S, Shneider BL, Suchy FJ. Sorting of rat liver and ileal sodium-dependent bile acid transporters in polarized epithelial cells. Am J Physiol. 1998 11; 275(5):G1045-55. PMID: 9815035.
      Citations: 15     Fields:    Translation:AnimalsCells
    32. Thevananther S, Kolli AH, Devarajan P. Identification of a novel ankyrin isoform (AnkG190) in kidney and lung that associates with the plasma membrane and binds alpha-Na, K-ATPase. J Biol Chem. 1998 Sep 11; 273(37):23952-8. PMID: 9727010.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    33. Shneider BL, Thevananther S, Moyer MS, Walters HC, Rinaldo P, Devarajan P, Sun AQ, Dawson PA, Ananthanarayanan M. Cloning and characterization of a novel peptidase from rat and human ileum. J Biol Chem. 1997 Dec 05; 272(49):31006-15. PMID: 9388249.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    34. Shneider BL, Fox VL, Schwarz KB, Watson CL, Ananthanarayanan M, Thevananther S, Christie DM, Hardikar W, Setchell KD, Mieli-Vergani G, Suchy FJ, Mowat AP. Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. Hepatology. 1997 May; 25(5):1176-83. PMID: 9141436.
      Citations: 18     Fields:    Translation:HumansAnimals
    35. Christie DM, Dawson PA, Thevananther S, Shneider BL. Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum. Am J Physiol. 1996 Aug; 271(2 Pt 1):G377-85. PMID: 8770054.
      Citations: 35     Fields:    Translation:AnimalsCells
    36. Brecher AS, Thevananther S, Wilson S. Observation of high and low molecular weight inhibitors of angiotensin-converting enzyme in rat lung. Arch Int Pharmacodyn Ther. 1996 May-Jun; 331(3):301-12. PMID: 9125001.
      Citations: 4     Fields:    Translation:Animals
    37. Thevananther S, Brecher AS. Interaction of acetaldehyde with plasma proteins of the renin-angiotensin system. Alcohol. 1994 Nov-Dec; 11(6):493-9. PMID: 7865150.
      Citations: 7     Fields:    Translation:Animals
    38. Brecher AS, Thevananther S, Franco-Saenz R. Acetaldehyde inhibits the anti-elastase activity of alpha 1-antitrypsin. Alcohol. 1994 May-Jun; 11(3):181-5. PMID: 8060517.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    39. Thevananther S, Brecher AS. Acetaldehyde inhibits angiotensin-converting enzyme activity of bovine lung. Alcohol. 1993 Nov-Dec; 10(6):545-8. PMID: 8123215.
      Citations: 2     Fields:    Translation:Animals
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