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GEOFFREY PREIDIS

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6621 FANNIN
ORCID ORCID Icon0000-0002-2206-6452 Additional info
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    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MAA.B., cum laude05/2003Physics
    Baylor College of Medicine, Houston, TXPh.D.02/2011Translational Biology and Molecular Medicine
    Baylor College of Medicine, Houston, TXM.D.05/2012
    Baylor College of Medicine, Houston, TXInternship06/2013Pediatrics
    Baylor College of Medicine, Houston, TXResidency06/2014Pediatrics
    Baylor College of Medicine, Houston, TXFellowship06/2018Pediatric Gastroenterology, Hepatology & Nutrition
    Collapse awards and honors
    2022 - 2027The metabolic basis for impaired bile acid synthesis in malnutrition (R01), National Institute of Diabetes and Digestive and Kidney Diseases
    2021 - 2023Impaired bile acid synthesis due to CYP7A1 and CYP7B1 suppression in malnutrition (R03), National Institute of Diabetes and Digestive and Kidney Diseases
    2017 - 2022Mentored Clinical Scientist Research Career Development Award (K08), National Institute of Diabetes and Digestive and Kidney Diseases
    2017 - 2017Chao Physician-Scientist Award, Ting Tsung and Wei Fong Chao Foundation
    2017 - 2017AGA-Rome Foundation Functional GI and Motility Pilot Award, American Gastroenterological Association / Rome Foundation
    2017 - 2017ANMS Research Grant, American Neurogastroenterology and Motility Society
    2016 - 2017Functional and Mechanistic Award, Akek Center for Metagenomics and Microbial Research
    2016 - 2018The Texas Medical Center Digestive Disease Center Pilot/Feasibility Award, The Texas Medical Digestive Diseases Center
    2015 - 2017NASPGHAN Foundation / Nestle Nutrition Research Young Investigator Development Award, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition
    2015 - 2017Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (T32), National Institute of Diabetes and Digestive and Kidney Diseases
    2013 - 2014Thrasher Research Fund Early Career Award, Thrasher Research Fund
    2013 - 2014Young Investigator Grant for Probiotics Research, Global Probiotics Council, Global Probiotics Council
    2009 - 2012Ruth L. Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows (F30), National Institute of Diabetes and Digestive and Kidney Diseases
    2022Inductee, Society for Pediatric Research
    2022Young Investigator Award, Department of Pediatrics, Baylor College of Medicine

    Collapse Overview 
    Collapse overview
    Our goal is to define mechanisms through which early life undernutrition alters metabolism and to determine how undernutrition influences intestinal and liver function. Undernutrition causes acute medical problems, but also long term health problems that may result from permanent epigenetic changes that alter transcription or via changes in the gut microbiome. Current studies focus on how malnutrition alters hepatic secretion, transcriptional programming, gastrointestinal motility, and host-microbiome interactions to impact growth. Our work is pertinent to those suffering from nutritional deficiencies caused by a wide range of medical and socioeconomic factors, including preterm and underweight newborns in the neonatal intensive care unit, children with severe acute malnutrition in the developing world, and adolescents with anorexia nervosa.

    Collapse Research 
    Collapse research activities and funding
    R13GM157901     (PREIDIS, GEOFFREY A)Dec 3, 2024 - Nov 30, 2025
    NIH
    2025 APSA South Regional Conference Meeting the Needs: Fostering a Future with Diverse Physician Scientists
    Role: Principal Investigator
    T32DK007664     (SHULMAN, ROBERT J)Jul 1, 2023 - Jun 30, 2025
    NIH
    Training grant in pediatric gastroenterology
    Role: Primary Research Mentor to Carine Halaby, MD
    R01DK135602     (HAIR, AMY B)May 15, 2023 - Mar 31, 2028
    NIH
    Liver-gut-microbiome axis and fatty acid absorption in preterm infants
    Role: Co-Investigator
    R01DK129579     (WOOTON-KEE, CLAVIA RUTH)Jul 15, 2022 - Jul 31, 2027
    NIH
    Nuclear receptor dysfunction reprograms metabolism and cellular proliferation in Wilson's disease
    Role: Co-Investigator
    R01DK133301     (PREIDIS, GEOFFREY A)Jul 15, 2022 - May 31, 2027
    NIH
    The metabolic basis for impaired bile acid synthesis in malnutrition
    Role: Principal Investigator
    R03DK129495     (PREIDIS, GEOFFREY A)Jul 15, 2021 - Jun 30, 2023
    NIH
    Impaired bile acid synthesis due to CYP7A1 and CYP7B1 suppression in malnutrition
    Role: Principal Investigator
    Private     (HAIR, AMY B; PREIDIS, GEOFFREY A)May 6, 2020 - May 5, 2021
    Men of Distinction
    Neonatal Gastroenterology, Hepatology & Nutrition Program
    Role Description: The goal of this study is to characterize maturation profiles of fecal bile acids and the metagenome over time among severely premature infants, and to associate specific profiles with perinatal growth.
    Role: Co-Principal Investigator
    K08DK113114     (PREIDIS, GEOFFREY A)Sep 1, 2017 - Aug 31, 2022
    NIH
    Nuclear receptor mediated bile acid alterations and coagulopathy in protein-energy undernutrition
    Role: Principal Investigator
    Private     (PREIDIS, GEOFFREY A)Jul 1, 2017 - Jun 30, 2018
    AGA-Rome Foundation Functional GI and Motility Disorders Pilot Research Award
    Bile Acid Mediated Dysmotility in Protein-Energy Undernutrition
    Role Description: This proposal sought to identify the role of decreased intestinal bile acid receptor signaling in undernutrition-associated gastrointestinal dysmotility.
    Role: Principal Investigator
    Private     (PREIDIS, GEOFFREY A)Jul 1, 2017 - Aug 31, 2017
    The Ting Tsung and Wei Fong Chao Foundation, Chao Physician-Scientist Award
    Nuclear Receptor Mediated Bile Acid Alterations and Coagulopathy in Protein-Energy Undernutrition
    Role Description: The goal of this award were to understand how the altered ratio of activation between two nuclear receptors, FXR and PPARa, influences the decreased hepatic synthesis of bile acids and coagulation factors, two hallmark features of severe undernutrition; this award provides support for early-career scientists who are actively pursuing NIH K-level funding.
    Role: Principal Investigator
    Private     (PREIDIS, GEOFFREY A)Feb 1, 2017 - Jun 30, 2017
    The American Neurogastroenterology and Motility Society Research Grant
    Bile Acids and Intestinal Dysmotility in Early Life Undernutrition
    Role Description: This proposal sought to identify nutrition-sensitive mechanisms that underlie gastrointestinal dysmotility; in particular, the role of altered bile acid receptor signaling was investigated.
    Role: Principal Investigator
    Private     (PREIDIS, GEOFFREY A)Nov 1, 2016 - Jun 30, 2017
    The Alkek Center for Metagenomics and Microbiome Research Functional and Mechanistic Award
    Microbial Mechanisms of Pathogenesis Underlying non-Helicobacter Gastritis
    Role Description: The aim of this study was to determine gastric mucosal microbes and microbial virulence factors associated with non-Helicobacter gastritis in children.
    Role: Principal Investigator
    U01DK112194     (PREIDIS, GEOFFREY A)Sep 25, 2016 - Jul 31, 2027
    NIH
    Advancing Clinical Science in Pediatric Gastroparesis
    Role: Co-Principal Investigator
    P30DK56338     (EL-SERAG, HASHEM B & PREIDIS, GEOFFREY A)Feb 1, 2016 - Jan 31, 2018
    NIH/NIDDK
    Persistent Epigenetic Changes in Early Undernutrition
    Role Description: The goal of this Pilot/Feasibility Award supported by the Texas Medical Center Digestive Diseases Center was to elucidate epigenetic mechanisms by which nutritional insults in early life lead to persistent changes in hepatocyte gene expression and development of metabolic diseases later in life.
    Role: Principal Investigator
    Private     (PREIDIS, GEOFFREY A)Nov 15, 2015 - Nov 14, 2017
    NASPGHAN Foundation/ Nestle Nutrition Research Young Investigator Development Award
    Glycan Metabolism Shapes the Undernourished Intestinal Microbiome and Influences Weight Gain
    Role Description: The goals of this award were to identify mechanisms by which a calorie- and protein-deficient diet alters the composition of intestinal microbes, and to identify the resulting effects on the undernourished intestine and host.
    Role: Principal Investigator
    T32DK007664     (SHULMAN, ROBERT J)Jul 1, 2015 - Aug 31, 2017
    NIH/NIDDK
    Mechanisms of Dysregulation of Bile Acid Synthesis in Protein-Energy Undernutrition
    Role Description: The goal of this Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant was to expand my areas of basic science expertise through a mentored basic science training experience with David D. Moore, Ph.D., international expert in nuclear hormone receptor regulation of bile acid signaling.
    Role: Trainee
    Private     (PREIDIS, GEOFFREY A)Oct 1, 2013 - Sep 30, 2014
    Thrasher Research Fund Early Career Award
    The Intestinal Microbiome as a Biomarker and Therapeutic Target in Severe Acute Malnutrition
    Role Description: This proposal aimed to identify specific gut bacteria and microbial genes associated with malnutrition, and sought to determine whether the disruptions to gut microbial communities due to early starvation persist after refeeding.
    Role: Principal Investigator
    Private     (PREIDIS, GEOFFREY A)Jul 1, 2013 - Jun 30, 2014
    Young Investigator Grant for Probiotics Research, Global Probiotics Council
    Elucidating the Role of the Intestinal Microbiome in Protein-Energy Undernutrition
    Role Description: This proposal aimed to use metabolomics and metagenomics approaches to determine how bacteria living in the gut contribute to the harmful effects of severe malnutrition, or to the protection of children against food shortages.
    Role: Principal Investigator
    F30DK081269     (PREIDIS, GEOFFREY A)Jun 1, 2009 - May 31, 2012
    NIH
    Mechanisms of Immunomodulation by Probiotic L. reuteri in Acute Gastroenteritis
    Role: Principal Investigator
    P30DK056338     (EL-SERAG, HASHEM B)Dec 1, 1999 - May 31, 2028
    NIH
    Texas Medical Center Digestive Diseases Center
    Role: Director of the Enrichment Program

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Amin A, Osborne S, Preidis GA, Gowda SH. Acute Liver Failure in a Neonate. Neoreviews. 2025 Aug 01; 26(8):e560-e563. PMID: 40744457.
      Citations:    Fields:    
    2. Wan X, Soni KG, Choi JM, Jung SY, Conner ME, Preidis GA. Inhibition of SREBP-1c rescues hepatic CYP7B1 expression and bile acid synthesis in malnourished mice. Am J Physiol Gastrointest Liver Physiol. 2025 Jul 01; 329(1):G232-G243. PMID: 40560816; PMCID: PMC12306192.
      Citations:    Fields:    Translation:AnimalsCells
    3. Britton RA, Verdu EF, Di Rienzi SC, Muñoz AR, Tarr PI, Preidis GA, Biotherapeutics Subcommittee of the AGA Center for Gut Microbiome Research and Education, Britton RA, Verdu EF, Di Rienzi SC, Reyes Mu?oz A, Tarr PI, Preidis GA, Tarr PI. Taking Microbiome Science to the Next Level: Recommendations to Advance the Emerging Field of Microbiome-Based Therapeutics and Diagnostics. Gastroenterology. 2024 Nov; 167(6):1059-1064. PMID: 38815708.
      Citations: 7     Fields:    
    4. Chang DS, Soni KG, Preidis GA. Smooth muscle contractile responses to bile acids in mouse ileum require TGR5 but not ASBT. Front Neurol. 2024; 15:1334319. PMID: 38721114; PMCID: PMC11076673.
      Citations: 3     
    5. Patel H, Harris RA, Qian JH, Oezguen N, Watson A, Szigeti RG, Cho S, Ruan W, Britto S, Opekun A, Preidis G, Kellermayer R, Kellermayer R. Genetic Variation Between Small Bowel and Colon-Predominant Crohn's Disease. Cell Mol Gastroenterol Hepatol. 2024; 17(6):1069-1071. PMID: 38369131; PMCID: PMC11127623.
      Citations:    Fields:    Translation:Humans
    6. Adeniyi-Ipadeola GO, Hoffman KL, Yang H, Javornik Cregeen SJ, Preidis GA, Ramani S, Hair AB. Human milk cream alters intestinal microbiome of preterm infants: a prospective cohort study. Pediatr Res. 2024 May; 95(6):1564-1571. PMID: 38228744.
      Citations:    Fields:    Translation:HumansCells
    7. PREIDIS GA. Nutrition-associated disease. In: Manson's Tropical Infectious Diseases (Farrar J, Hotez P, Junghanss T, Kang G, Lalloo D, White NJ, Garcia PJ, Eds). 2023; 1161-1177.
    8. Shane AL, Preidis GA. Probiotics in the Neonatal Intensive Care Unit-A Framework for Optimizing Product Standards. JAMA Pediatr. 2023 09 01; 177(9):879-880. PMID: 37428483.
      Citations: 10     Fields:    Translation:Humans
    9. Lynch LE, Hair AB, Soni KG, Yang H, Gollins LA, Narvaez-Rivas M, Setchell KDR, Preidis GA. Cholestasis impairs gut microbiota development and bile salt hydrolase activity in preterm neonates. Gut Microbes. 2023 Jan-Dec; 15(1):2183690. PMID: 36843227; PMCID: PMC9980517.
      Citations: 11     Fields:    Translation:Humans
    10. PREIDIS GA, Chumpitazi BP, Shulman RJ. The microbiome in neurogastroenterology. In: Pediatric Neurogastroenterology: Gastrointestinal Motility Disorders and Disorders of Gut Brain Interaction in Children (Faure C, Thapar N, Di Lorenzo C, Eds.). 2022; 80-100.
    11. Holzapfel LF, Hair AB, Preidis GA, Halder T, Yang H, Unger JP, Freedman S, Martin CR. Fecal Elastase in Preterm Infants to Predict Growth Outcomes. J Pediatr Gastroenterol Nutr. 2023 02 01; 76(2):206-212. PMID: 36705701; PMCID: PMC9886337.
      Citations:    Fields:    Translation:Humans
    12. Preidis GA. Rational Probiotic Strain Selection to Prevent Necrotizing Enterocolitis. J Pediatr Gastroenterol Nutr. 2022 10 01; 75(4):387-388. PMID: 35881959; PMCID: PMC9489650.
      Citations: 1     Fields:    Translation:Humans
    13. Preidis GA, Su GL, Morgan RL. Reply. Gastroenterology. 2021 06; 160(7):2633-2635. PMID: 33639156.
      Citations:    Fields:    Translation:HumansCells
    14. Preidis GA, Soni KG, Suh JH, Halder T, Kim KH, Choi JM, Li F, Devaraj S, Conner ME, Coarfa C, Jung SY, Moore DD. Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors. Hepatol Commun. 2020 Dec; 4(12):1835-1850. PMID: 33305154; PMCID: PMC7706303.
      Citations: 4     Fields:    
    15. Soni KG, Halder T, Conner ME, Preidis GA. Sexual dimorphism in upper gastrointestinal motility is dependent on duration of fast, time of day, age, and strain of mice. Neurogastroenterol Motil. 2019 09; 31(9):e13654. PMID: 31157504; PMCID: PMC6693981.
      Citations: 1     Fields:    Translation:Animals
    16. Ford SL, Lohmann P, Preidis GA, Gordon PS, O'Donnell A, Hagan J, Venkatachalam A, Balderas M, Luna RA, Hair AB. Improved feeding tolerance and growth are linked to increased gut microbial community diversity in very-low-birth-weight infants fed mother's own milk compared with donor breast milk. Am J Clin Nutr. 2019 04 01; 109(4):1088-1097. PMID: 30982856; PMCID: PMC6462428.
      Citations: 23     Fields:    Translation:HumansCellsCTClinical Trials
    17. 21. Alves da Silva AV, de Castro Olveira SB, Di Rienzi SC, Brown-Steinke K, Dehan LM, Rood JK, Carreira VS, Le H, Maier EA, Betz KJ, Aihara E, Ley RE, PREIDIS GA, Shen L, Moore SR. Murine methyl donor deficiency impairs early growth in association with dysmorphic small intestinal crypts and reduced gut microbial diversity. Curr Dev Nutr. 2019; 3:nzy070.
    18. Thaxton GE, Melby PC, Manary MJ, Preidis GA. New Insights into the Pathogenesis and Treatment of Malnutrition. Gastroenterol Clin North Am. 2018 12; 47(4):813-827. PMID: 30337034; PMCID: PMC6484436.
      Citations: 5     Fields:    Translation:Humans
    19. Shin A, Preidis GA, Shulman R, Kashyap PC. The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders. Clin Gastroenterol Hepatol. 2019 01; 17(2):256-274. PMID: 30153517; PMCID: PMC6314902.
      Citations: 39     Fields:    Translation:HumansAnimals
    20. Preidis GA, Kim KH, Moore DD. Nutrient-sensing nuclear receptors PPARa and FXR control liver energy balance. J Clin Invest. 2017 Apr 03; 127(4):1193-1201. PMID: 28287408; PMCID: PMC5373864.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    21. Berko ER, Cho MT, Eng C, Shao Y, Sweetser DA, Waxler J, Robin NH, Brewer F, Donkervoort S, Mohassel P, Bönnemann CG, Bialer M, Moore C, Wolfe LA, Tifft CJ, Shen Y, Retterer K, Millan F, Chung WK. De novo missense variants in HECW2 are associated with neurodevelopmental delay and hypotonia. J Med Genet. 2017 02; 54(2):84-86. PMID: 30643852; PMCID: PMC5222737.
      Citations:    
    22. Preidis GA, Luna RA, Hollister EB, Schady D, Gao C, Finegold MJ, Versalovic J, Shulman RJ. The mucosal microbiota in a young child with severe non-Helicobacter gastritis. Therap Adv Gastroenterol. 2016 Sep; 9(5):749-51. PMID: 27582889; PMCID: PMC4984332.
      Citations:    
    23. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Microbial-Derived Metabolites Reflect an Altered Intestinal Microbiota during Catch-Up Growth in Undernourished Neonatal Mice. J Nutr. 2016 05; 146(5):940-8. PMID: 27052538; PMCID: PMC4841929.
      Citations: 9     Fields:    Translation:AnimalsCells
    24. PREIDIS GA, Chumpitazi BP, Shulman RJ. Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children. Faure C, Thapar N, Di Lorenzo C, Eds. The microbiome in neurogastroenterology. 2016.
    25. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Composition and function of the undernourished neonatal mouse intestinal microbiome. J Nutr Biochem. 2015 Oct; 26(10):1050-7. PMID: 26070414.
      Citations: 21     Fields:    Translation:AnimalsCells
    26. Preidis GA, Hotez PJ. The newest "omics"--metagenomics and metabolomics--enter the battle against the neglected tropical diseases. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003382. PMID: 25675250; PMCID: PMC4326130.
      Citations: 19     Fields:    
    27. LaCourse SM, Chester FM, Preidis G, McCrary LM, Maliwichi M, McCollum ED, Hosseinipour MC. Lay-screeners and use of WHO growth standards increase case finding of hospitalized Malawian children with severe acute malnutrition. J Trop Pediatr. 2015 Feb; 61(1):44-53. PMID: 25477308; PMCID: PMC4375387.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    28. Perry SH, Swamy P, Preidis GA, Mwanyumba A, Motsa N, Sarero HN. Implementing the Jadelle implant for women living with HIV in a resource-limited setting: concerns for drug interactions leading to unintended pregnancies. AIDS. 2014 Mar 13; 28(5):791-3. PMID: 24401645.
      Citations: 29     Fields:    Translation:Humans
    29. Preidis GA, Keaton MA, Campeau PM, Bessard BC, Conner ME, Hotez PJ. The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress. J Nutr. 2014 Mar; 144(3):273-81. PMID: 24381221; PMCID: PMC3927544.
      Citations: 19     Fields:    Translation:AnimalsCells
    30. Kim MH, Ahmed S, Preidis GA, Abrams EJ, Hosseinipour MC, Giordano TP, Chiao EY, Paul ME, Bhalakia A, Nanthuru D, Kazembe PN. Low rates of mother-to-child HIV transmission in a routine programmatic setting in Lilongwe, Malawi. PLoS One. 2013; 8(5):e64979. PMID: 23741437; PMCID: PMC3669205.
      Citations: 22     Fields:    Translation:HumansPHPublic Health
    31. Kim MH, Ahmed S, Buck WC, Preidis GA, Hosseinipour MC, Bhalakia A, Nanthuru D, Kazembe PN, Chimbwandira F, Giordano TP, Chiao EY, Schutze GE, Kline MW. The Tingathe programme: a pilot intervention using community health workers to create a continuum of care in the prevention of mother to child transmission of HIV (PMTCT) cascade of services in Malawi. J Int AIDS Soc. 2012 Jul 11; 15 Suppl 2:17389. PMID: 22789644; PMCID: PMC3499848.
      Citations: 66     Fields:    Translation:HumansPHPublic Health
    32. Thomas CM, PREIDIS GA, Versalovic J. Mechanisms of immune enhancement by beneficial microbes and probiotics. Old Herborn Univ Semin Monographs. 2011; 24:83-94.
    33. PREIDIS GA. Mechanisms of probiosis by Lactobacillus reuteri in acute rotaviral gastroenteritis: implications for enteric and diarrheal diseases in the developing world. 2011.
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