ZAP-70 Protein-Tyrosine Kinase
"ZAP-70 Protein-Tyrosine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR function.
| Descriptor ID |
D051746
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.900 D12.776.476.950
|
| Concept/Terms |
ZAP-70 Protein-Tyrosine Kinase- ZAP-70 Protein-Tyrosine Kinase
- Protein-Tyrosine Kinase, ZAP-70
- ZAP 70 Protein Tyrosine Kinase
- ZAP-70 Kinase
- Kinase, ZAP-70
- ZAP 70 Kinase
- zeta-Chain Associated Protein Kinase (ZAP-70)
- 70 kDa Zeta-Associated Protein
- 70 kDa Zeta Associated Protein
- ZAP-70 Protein
- ZAP 70 Protein
- Syk-Related Tyrosine Kinase
- Syk Related Tyrosine Kinase
- Tyrosine Kinase, Syk-Related
|
Below are MeSH descriptors whose meaning is more general than "ZAP-70 Protein-Tyrosine Kinase".
Below are MeSH descriptors whose meaning is more specific than "ZAP-70 Protein-Tyrosine Kinase".
This graph shows the total number of publications written about "ZAP-70 Protein-Tyrosine Kinase" by people in this website by year, and whether "ZAP-70 Protein-Tyrosine Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2005 | 1 | 4 | 5 |
| 2006 | 2 | 2 | 4 |
| 2007 | 1 | 2 | 3 |
| 2008 | 1 | 3 | 4 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 2 | 3 |
| 2011 | 0 | 3 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 4 | 6 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "ZAP-70 Protein-Tyrosine Kinase" by people in Profiles.
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Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain. Front Immunol. 2023; 14:1155883.
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LPL deletion is associated with poorer response to ibrutinib-based treatments and overall survival in TP53-deleted chronic lymphocytic leukemia. Ann Hematol. 2020 Oct; 99(10):2343-2349.
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Time-dependent decline of T-cell receptor excision circle levels in ZAP-70 deficiency. J Allergy Clin Immunol Pract. 2020 02; 8(2):806-808.e2.
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Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat Commun. 2018 07 06; 9(1):2627.
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B-cell Receptor Signaling Regulates Metabolism in Chronic Lymphocytic Leukemia. Mol Cancer Res. 2017 12; 15(12):1692-1703.
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CD49d shows superior performance characteristics for flow cytometric prognostic testing in chronic lymphocytic leukemia/small lymphocytic lymphoma. Cytometry B Clin Cytom. 2018 01; 94(1):129-135.
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Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016 Mar 07; 213(3):399-414.
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?2 -microglobulin normalization within 6 months of ibrutinib-based treatment is associated with superior progression-free survival in patients with chronic lymphocytic leukemia. Cancer. 2016 Feb 15; 122(4):565-73.
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Blood collection methods affect cellular protein integrity: implications for clinical trial biomarkers and ZAP-70 in CLL. Blood. 2014 Aug 14; 124(7):1192-5.
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MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood. 2014 Jul 24; 124(4):546-54.