Ribosomal Protein S6 Kinases
"Ribosomal Protein S6 Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.
| Descriptor ID |
D019893
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| MeSH Number(s) |
D08.811.913.696.620.682.700.862 D12.644.360.600 D12.776.476.600
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases".
Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases".
This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases" by people in this website by year, and whether "Ribosomal Protein S6 Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 1999 | 3 | 1 | 4 |
| 2000 | 1 | 2 | 3 |
| 2001 | 0 | 4 | 4 |
| 2002 | 2 | 3 | 5 |
| 2003 | 1 | 2 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 2 | 6 | 8 |
| 2006 | 1 | 4 | 5 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 5 | 5 |
| 2009 | 1 | 7 | 8 |
| 2010 | 0 | 3 | 3 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 3 | 4 |
| 2013 | 0 | 3 | 3 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 2 | 2 |
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Below are the most recent publications written about "Ribosomal Protein S6 Kinases" by people in Profiles.
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Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model. Am J Clin Nutr. 2018 10 01; 108(4):830-841.
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In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2-CDK4/6 Targeting and mTOR-S6 Resistance Mechanisms. Cancer Discov. 2018 05; 8(5):568-581.
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Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. J Natl Cancer Inst. 2017 11 01; 109(11).
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Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas. Clin Cancer Res. 2017 Oct 15; 23(20):6215-6226.
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The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL. Leukemia. 2015 Sep; 29(9):1811-22.
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Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells. Cytometry A. 2015 Apr; 87(4):346-56.
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RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Mol Cancer Res. 2015 Feb; 13(2):348-57.
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Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab. 2013 Nov 01; 305(9):E1059-70.
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Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):E2572-81.
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Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLoS One. 2013; 8(3):e57808.