Ribosomal Protein S6 Kinases, 90-kDa
"Ribosomal Protein S6 Kinases, 90-kDa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
| Descriptor ID |
D038744
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.862.500 D12.644.360.600.500 D12.776.476.600.500
|
| Concept/Terms |
Ribosomal Protein S6 Kinases, 90-kDa- Ribosomal Protein S6 Kinases, 90-kDa
- Ribosomal Protein S6 Kinases, 90 kDa
- p90(rsk)
- MAP-Kinase-Activated Protein Kinase 1
- MAP Kinase Activated Protein Kinase 1
- MAPKAP Kinase-1
- MAPKAP Kinase 1
- MAP-Kinase-Activated Kinase 1
- MAP Kinase Activated Kinase 1
- Ribosomal Protein S6 Kinase, 90-kDa
- Ribosomal Protein S6 Kinase, 90 kDa
- p90 Ribosomal S6 Kinase
- MAPKAP-K1
- pp90(rsk)
- MAPKAPK1
|
Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases, 90-kDa".
Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases, 90-kDa".
This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in this website by year, and whether "Ribosomal Protein S6 Kinases, 90-kDa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2005 | 3 | 0 | 3 |
| 2006 | 3 | 2 | 5 |
| 2008 | 1 | 2 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 3 | 1 | 4 |
| 2013 | 3 | 1 | 4 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 3 | 1 | 4 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 1 | 3 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in Profiles.
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PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy. Diabetes. 2024 Nov 01; 73(11):1805-1820.
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p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer. BMC Cancer. 2024 Feb 19; 24(1):233.
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EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer. Cell Rep. 2022 12 13; 41(11):111827.
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Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1. EMBO J. 2021 04 01; 40(7):e106106.
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The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk. J Biol Chem. 2019 06 21; 294(25):9901-9910.
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MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight. 2019 04 04; 4(7).
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Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals. Circulation. 2019 02 26; 139(9):1199-1216.
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PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1. Hum Mol Genet. 2018 08 15; 27(16):2863-2873.
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Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer. Clin Cancer Res. 2017 Oct 15; 23(20):6239-6253.
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The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development. PLoS One. 2016; 11(12):e0166703.