Suppressor of Cytokine Signaling Proteins
"Suppressor of Cytokine Signaling Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.
| Descriptor ID |
D050826
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| MeSH Number(s) |
D12.644.360.024.374 D12.776.157.057.249 D12.776.476.024.437
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling Proteins".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling Proteins".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling Proteins" by people in this website by year, and whether "Suppressor of Cytokine Signaling Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 2 | 3 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2023 | 2 | 1 | 3 |
| 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling Proteins" by people in Profiles.
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Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort. Cancer Res. 2023 02 03; 83(3):386-397.
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Genetic association analysis of 30 genes related to obesity in a European American population. Int J Obes (Lond). 2014 May; 38(5):724-9.
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The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol. 2013 Jul; 14(7):732-40.
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IL-27 enhances the survival of tumor antigen-specific CD8+ T cells and programs them into IL-10-producing, memory precursor-like effector cells. Eur J Immunol. 2013 Feb; 43(2):468-79.
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Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol. 2012 May; 13(5):481-90.
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Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011 Jul 15; 71(14):4932-43.
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Suppression of innate immunity (natural killer cell/interferon-?) in the advanced stages of liver fibrosis in mice. Hepatology. 2011 Apr; 53(4):1342-51.
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Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metab. 2011 Mar 02; 13(3):331-9.
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Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res. 2011 May; 21(5):754-69.
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Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res. 2008 Dec 01; 68(23):9634-42.