Suppressor of Cytokine Signaling Proteins
"Suppressor of Cytokine Signaling Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.
| Descriptor ID |
D050826
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| MeSH Number(s) |
D12.644.360.024.374 D12.776.157.057.249 D12.776.476.024.437
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling Proteins".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling Proteins".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling Proteins" by people in this website by year, and whether "Suppressor of Cytokine Signaling Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 5 | 6 |
| 2008 | 1 | 3 | 4 |
| 2009 | 1 | 2 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 4 | 6 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 3 | 1 | 4 |
| 2021 | 1 | 0 | 1 |
| 2023 | 2 | 1 | 3 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling Proteins" by people in Profiles.
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Aberrant expression of SOCS impairs the anti-leishmanial immune response. Cytokine. 2024 02; 174:156461.
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Phenotypic Variability of SOCS1 Haploinsufficiency. J Clin Immunol. 2023 07; 43(5):902-906.
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Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort. Cancer Res. 2023 02 03; 83(3):386-397.
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Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells. Blood. 2021 02 04; 137(5):624-636.
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Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Blood. 2017 05 04; 129(18):2479-2492.
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Genes Involved in Maintaining the Bone Marrow Stroma Are Dysregulated in Patients with Myelofibrosis: Lenalidomide Treatment Up-regulates SOCS3. Anticancer Res. 2015 Oct; 35(10):5219-23.
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Axl modulates immune activation of smooth muscle cells in vein graft remodeling. Am J Physiol Heart Circ Physiol. 2015 Sep 15; 309(6):H1048-58.
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Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice. Gene Ther. 2015 Nov; 22(11):876-82.
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Milk yield differences between 1? and 4? milking are associated with changes in mammary mitochondrial number and milk protein gene expression, but not mammary cell apoptosis or SOCS gene expression. J Dairy Sci. 2015 Jul; 98(7):4439-48.
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Identification, phylogeny and expression analysis of suppressors of cytokine signaling in channel catfish. Mol Immunol. 2015 Apr; 64(2):276-84.