"GRB2 Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
| Descriptor ID |
D051380
|
| MeSH Number(s) |
D12.644.360.024.290 D12.776.157.057.041 D12.776.476.024.377
|
| Concept/Terms |
GRB2 Adaptor Protein- GRB2 Adaptor Protein
- Abundant Src Homology Protein
- Growth Factor Receptor-Bound Protein-2
- Growth Factor Receptor Bound Protein 2
|
Below are MeSH descriptors whose meaning is more general than "GRB2 Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "GRB2 Adaptor Protein".
This graph shows the total number of publications written about "GRB2 Adaptor Protein" by people in this website by year, and whether "GRB2 Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "GRB2 Adaptor Protein" by people in Profiles.
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Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ? in osteoclasts. J Biol Chem. 2014 Dec 26; 289(52):36048-58.
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Competition between Grb2 and Plc?1 for FGFR2 regulates basal phospholipase activity and invasion. Nat Struct Mol Biol. 2014 Feb; 21(2):180-8.
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Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity. J Cell Biol. 2013 Feb 18; 200(4):493-504.
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Inhibition of basal FGF receptor signaling by dimeric Grb2. Cell. 2012 Jun 22; 149(7):1514-24.
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Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling. Int J Biochem Cell Biol. 2010 Sep; 42(9):1462-71.
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Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest. 2010 Mar; 120(3):778-90.
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Liposome-incorporated Grb2 antisense oligodeoxynucleotide increases the survival of mice bearing bcr-abl-positive leukemia xenografts. Int J Oncol. 2007 Nov; 31(5):1243-50.
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Directed discovery of bivalent peptide ligands to an SH3 domain. Protein Sci. 2004 Mar; 13(3):626-32.
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Tyrosine phosphorylation-dependent yeast two-hybrid system for the identification of the SH2 domain-binding proteins. Mol Cells. 2001 Oct 31; 12(2):244-9.
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GRB2: a pivotal protein in signal transduction. Semin Oncol. 2001 Oct; 28(5 Suppl 16):142-7.