"GRB2 Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
| Descriptor ID |
D051380
|
| MeSH Number(s) |
D12.644.360.024.290 D12.776.157.057.041 D12.776.476.024.377
|
| Concept/Terms |
GRB2 Adaptor Protein- GRB2 Adaptor Protein
- Abundant Src Homology Protein
- Growth Factor Receptor-Bound Protein-2
- Growth Factor Receptor Bound Protein 2
|
Below are MeSH descriptors whose meaning is more general than "GRB2 Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "GRB2 Adaptor Protein".
This graph shows the total number of publications written about "GRB2 Adaptor Protein" by people in this website by year, and whether "GRB2 Adaptor Protein" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 3 | 0 | 3 |
| 2015 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "GRB2 Adaptor Protein" by people in Profiles.
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GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nat Commun. 2024 Mar 08; 15(1):2132.
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Regulation of microRNA expression by the adaptor protein GRB2. Sci Rep. 2023 06 16; 13(1):9784.
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Grb2 binding induces phosphorylation-independent activation of Shp2. Commun Biol. 2021 04 01; 4(1):437.
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Liposomal Grb2 antisense oligodeoxynucleotide (BP1001) in patients with refractory or relapsed haematological malignancies: a single-centre, open-label, dose-escalation, phase 1/1b trial. Lancet Haematol. 2018 Apr; 5(4):e136-e146.
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Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene. 2016 04 28; 35(17):2186-96.
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Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nat Commun. 2015 Jun 24; 6:7354.
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Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ? in osteoclasts. J Biol Chem. 2014 Dec 26; 289(52):36048-58.
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Competition between Grb2 and Plc?1 for FGFR2 regulates basal phospholipase activity and invasion. Nat Struct Mol Biol. 2014 Feb; 21(2):180-8.
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Targeting SH2 domains in breast cancer. Future Med Chem. 2014; 6(17):1909-26.
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Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity. J Cell Biol. 2013 Feb 18; 200(4):493-504.