A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.

Descriptor ID	D055504
MeSH Number(s)	D12.644.360.024.301 D12.776.157.057.045 D12.776.476.024.382
Concept/Terms	Insulin Receptor Substrate Proteins Insulin Receptor Substrate Proteins IRS Signaling Adaptor Proteins Insulin Receptor Substrate-1 Protein Insulin Receptor Substrate-1 Protein Insulin Receptor Substrate 1 Protein Insulin Receptor Substrate-1 Insulin Receptor Substrate 1 Insulin Receptor Substrate-4 Protein Insulin Receptor Substrate-4 Protein Insulin Receptor Substrate 4 Protein Insulin Receptor Substrate-4 Insulin Receptor Substrate 4 Insulin Receptor Substrate-2 Protein Insulin Receptor Substrate-2 Protein Insulin Receptor Substrate 2 Protein Insulin Receptor Substrate-2 Insulin Receptor Substrate 2 Insulin Receptor Substrate-3 Protein Insulin Receptor Substrate-3 Protein Insulin Receptor Substrate 3 Protein Insulin Receptor Substrate-3 Insulin Receptor Substrate 3

Below are MeSH descriptors whose meaning is more general than "Insulin Receptor Substrate Proteins".

Below are MeSH descriptors whose meaning is related to "Insulin Receptor Substrate Proteins".

Below are MeSH descriptors whose meaning is more specific than "Insulin Receptor Substrate Proteins".