Insulin Receptor Substrate Proteins
"Insulin Receptor Substrate Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
| Descriptor ID |
D055504
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| MeSH Number(s) |
D12.644.360.024.301 D12.776.157.057.045 D12.776.476.024.382
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Insulin Receptor Substrate Proteins".
Below are MeSH descriptors whose meaning is more specific than "Insulin Receptor Substrate Proteins".
This graph shows the total number of publications written about "Insulin Receptor Substrate Proteins" by people in this website by year, and whether "Insulin Receptor Substrate Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 4 | 4 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 4 | 4 |
| 2006 | 0 | 8 | 8 |
| 2007 | 0 | 4 | 4 |
| 2008 | 0 | 5 | 5 |
| 2009 | 3 | 3 | 6 |
| 2010 | 2 | 4 | 6 |
| 2011 | 1 | 2 | 3 |
| 2012 | 2 | 4 | 6 |
| 2013 | 2 | 2 | 4 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 2 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "Insulin Receptor Substrate Proteins" by people in Profiles.
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Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin. Nat Commun. 2021 09 06; 12(1):5296.
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The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1. J Biol Chem. 2021 Jan-Jun; 296:100739.
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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat Commun. 2021 01 05; 12(1):24.
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Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6).
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Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40. Am J Physiol Endocrinol Metab. 2020 05 01; 318(5):E625-E635.
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Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study. Hum Mol Genet. 2019 08 15; 28(16):2659-2674.
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Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. J Natl Cancer Inst. 2017 08 01; 109(8).
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Gestational Protein Restriction Impairs Glucose Disposal in the Gastrocnemius Muscles of Female Rats. Endocrinology. 2017 04 01; 158(4):756-767.
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IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma. J Natl Cancer Inst. 2016 12; 108(12).
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Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-a-induced hepatic insulin resistance. Sci Rep. 2015 Dec 15; 5:18093.