Nuclear Receptor Coactivators
"Nuclear Receptor Coactivators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes.
| Descriptor ID |
D056918
|
| MeSH Number(s) |
D12.644.360.024.314 D12.776.157.057.080 D12.776.476.024.394 D12.776.660.675 D12.776.930.617
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Coactivators".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Coactivators".
This graph shows the total number of publications written about "Nuclear Receptor Coactivators" by people in this website by year, and whether "Nuclear Receptor Coactivators" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 4 | 2 | 6 |
| 2011 | 3 | 0 | 3 |
| 2012 | 2 | 1 | 3 |
| 2013 | 4 | 0 | 4 |
| 2014 | 2 | 1 | 3 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2024 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Nuclear Receptor Coactivators" by people in Profiles.
-
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov. 2024 Aug 02; 14(8):1476-1495.
-
Steroid receptor coactivators in Treg and Th17 cell biology and function. Front Immunol. 2024; 15:1389041.
-
Steroid receptor coactivators - their role in immunity. Front Immunol. 2022; 13:1079011.
-
Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family. Endocrinology. 2021 03 01; 162(3).
-
Emerging roles of steroid receptor coactivators in stromal cell responses. J Endocrinol. 2021 02; 248(2):R41-R50.
-
Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain. Endocrinology. 2020 08 01; 161(8).
-
The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ERa and enhancing enhancer-promoter interactions. J Biol Chem. 2019 12 20; 294(51):19667-19682.
-
Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer. Clin Cancer Res. 2016 Nov 15; 22(22):5403-5407.
-
The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets. Horm Cancer. 2016 08; 7(4):229-35.
-
MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet ?-Cell Function. Diabetes. 2015 Nov; 64(11):3772-83.