Myeloid Ecotropic Viral Integration Site 1 Protein
"Myeloid Ecotropic Viral Integration Site 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TALE-type homeodomain protein and transcription factor that functions as a regulator of PAX6 PROTEIN expression and as an activator of PLATELET FACTOR 4 gene expression. It is essential for hematopoiesis, differentiation of MEGAKARYOCYTES, and vascular patterning. It may also have a role in the induction of myeloid leukemias.
| Descriptor ID |
D000075064
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| MeSH Number(s) |
D12.776.260.400.483 D12.776.930.462
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Myeloid Ecotropic Viral Integration Site 1 Protein".
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Below are the most recent publications written about "Myeloid Ecotropic Viral Integration Site 1 Protein" by people in Profiles.
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HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. Prostate. 2019 03; 79(4):414-424.
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Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife. 2016 Feb 08; 5.
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All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biol Ther. 2014 Apr; 15(4):463-72.
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Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress. Blood. 2012 Dec 13; 120(25):4973-81.
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Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells. Blood. 2012 Dec 13; 120(25):4963-72.
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Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease. Circ Res. 2008 Sep 26; 103(7):702-9.
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HOX expression patterns identify a common signature for favorable AML. Leukemia. 2008 Nov; 22(11):2041-7.
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Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3945-50.
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Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J. 2004 Jan 28; 23(2):450-9.
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Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol Cell Biol. 1997 Oct; 17(10):5679-87.