Zinc Finger E-box-Binding Homeobox 1
"Zinc Finger E-box-Binding Homeobox 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.
| Descriptor ID |
D000071799
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| MeSH Number(s) |
D12.776.260.400.906 D12.776.260.703.800 D12.776.930.780.945
|
| Concept/Terms |
Zinc Finger E-box-Binding Homeobox 1- Zinc Finger E-box-Binding Homeobox 1
- Zinc Finger E box Binding Homeobox 1
- NIL-2-A Zinc Finger Protein
- NIL 2 A Zinc Finger Protein
- TCF8 Protein
- Zeb1 Transcription Factor
- Transcription Factor, Zeb1
- Transcription Factor 8
|
Below are MeSH descriptors whose meaning is more general than "Zinc Finger E-box-Binding Homeobox 1".
Below are MeSH descriptors whose meaning is more specific than "Zinc Finger E-box-Binding Homeobox 1".
This graph shows the total number of publications written about "Zinc Finger E-box-Binding Homeobox 1" by people in this website by year, and whether "Zinc Finger E-box-Binding Homeobox 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 3 | 3 | 6 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Finger E-box-Binding Homeobox 1" by people in Profiles.
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ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis. Mol Cancer Res. 2023 08 01; 21(8):779-794.
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EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancer. Proc Natl Acad Sci U S A. 2023 07 11; 120(28):e2220276120.
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EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer. J Clin Invest. 2023 04 03; 133(7).
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ZEB1-regulated lnc-Nr2f1 promotes the migration and invasion of lung adenocarcinoma cells. Cancer Lett. 2022 05 01; 533:215601.
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Transcriptional control of a collagen deposition and adhesion process that promotes lung adenocarcinoma growth and metastasis. JCI Insight. 2022 01 11; 7(1).
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The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells. Nat Commun. 2021 11 03; 12(1):6354.
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Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc. Signal Transduct Target Ther. 2021 06 25; 6(1):240.
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Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity. Cell Rep. 2021 04 20; 35(3):109009.
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Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer. Cell Rep. 2021 04 13; 35(2):108990.
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Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis. Mol Cancer Res. 2021 05; 19(5):784-798.