"CCCTC-Binding Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
| Descriptor ID |
D000076246
|
| MeSH Number(s) |
D12.776.157.687.157 D12.776.260.120 D12.776.660.235.050 D12.776.660.720.157 D12.776.664.235.050 D12.776.930.780.563
|
| Concept/Terms |
CCCTC-Binding Factor- CCCTC-Binding Factor
- CCCTC Binding Factor
- DNA-Binding Protein CTCF
- CTCF, DNA-Binding Protein
- DNA Binding Protein CTCF
- CTCF Protein
|
Below are MeSH descriptors whose meaning is more general than "CCCTC-Binding Factor".
Below are MeSH descriptors whose meaning is more specific than "CCCTC-Binding Factor".
This graph shows the total number of publications written about "CCCTC-Binding Factor" by people in this website by year, and whether "CCCTC-Binding Factor" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 4 | 4 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 2 | 2 |
| 2020 | 1 | 2 | 3 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 3 | 3 |
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Below are the most recent publications written about "CCCTC-Binding Factor" by people in Profiles.
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CTCF is essential for proper mitotic spindle structure and anaphase segregation. Chromosoma. 2024 Jul; 133(3):183-194.
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Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res. 2023 09 08; 51(16):8447-8462.
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Chromatin alternates between A and B compartments at kilobase scale for subgenic organization. Nat Commun. 2023 06 06; 14(1):3303.
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Enhancer-promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness. Nat Genet. 2023 02; 55(2):280-290.
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Myotonic dystrophy type 1 (DM1) clinical subtypes and CTCF site methylation status flanking the CTG expansion are mutant allele length-dependent. Hum Mol Genet. 2021 12 27; 31(2):262-274.
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CTCF looping is established during gastrulation in medaka embryos. Genome Res. 2021 06; 31(6):968-980.
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Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders. Nat Commun. 2020 10 01; 11(1):4932.
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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation. Genome Biol. 2020 09 15; 21(1):247.
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Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity. Mol Cell. 2020 05 07; 78(3):506-521.e6.
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Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication. Cell. 2019 02 07; 176(4):816-830.e18.