DNA Topoisomerases, Type I
"DNA Topoisomerases, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
| Descriptor ID |
D004264
|
| MeSH Number(s) |
D08.811.399.403.483 D12.776.157.687.375 D12.776.660.720.375
|
| Concept/Terms |
DNA Topoisomerases, Type I- DNA Topoisomerases, Type I
- DNA Nicking-Closing Proteins
- DNA Relaxing Enzyme
- DNA Relaxing Enzymes
- DNA Relaxing Protein
- DNA Topoisomerase
- DNA Topoisomerase I
- DNA Type 1 Topoisomerase
- DNA Untwisting Enzyme
- DNA Untwisting Enzymes
- DNA Untwisting Protein
- DNA Untwisting Proteins
- Topoisomerase I
- Type I DNA Topoisomerase
- DNA Nicking-Closing Protein
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases, Type I".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases, Type I".
This graph shows the total number of publications written about "DNA Topoisomerases, Type I" by people in this website by year, and whether "DNA Topoisomerases, Type I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "DNA Topoisomerases, Type I" by people in Profiles.
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RNA interacts with topoisomerase I to adjust DNA topology. Mol Cell. 2024 09 05; 84(17):3192-3208.e11.
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The acidic C-terminal tail of DNA Gyrase of Salmonella enterica serovar Typhi controls DNA relaxation in an acidic environment. Int J Biol Macromol. 2024 Mar; 261(Pt 1):129728.
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The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity. PLoS One. 2019; 14(5):e0215696.
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TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase. Nucleic Acids Res. 2018 01 25; 46(2):861-872.
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Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. Nucleic Acids Res. 2017 Jun 02; 45(10):5850-5862.
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Selective transport of cationized fluorescent topoisomerase into nuclei of live cells for DNA damage studies. Methods Mol Biol. 2014; 1094:167-75.
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In vitro assembly of semi-artificial molecular machine and its use for detection of DNA damage. J Vis Exp. 2012 Jan 11; (59):e3628.
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Cigarette smoking is not a risk factor for systemic sclerosis. Arthritis Rheum. 2011 Oct; 63(10):3098-102.
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Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts. Arthritis Res Ther. 2011 Aug 09; 13(4):R128.
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Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells. Mol Cell Biol. 2011 Aug; 31(15):3105-12.