DNA Topoisomerases, Type I
"DNA Topoisomerases, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
| Descriptor ID |
D004264
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| MeSH Number(s) |
D08.811.399.403.483 D12.776.157.687.375 D12.776.660.720.375
|
| Concept/Terms |
DNA Topoisomerases, Type I- DNA Topoisomerases, Type I
- DNA Nicking-Closing Proteins
- DNA Relaxing Enzyme
- DNA Relaxing Enzymes
- DNA Relaxing Protein
- DNA Topoisomerase
- DNA Topoisomerase I
- DNA Type 1 Topoisomerase
- DNA Untwisting Enzyme
- DNA Untwisting Enzymes
- DNA Untwisting Protein
- DNA Untwisting Proteins
- Topoisomerase I
- Type I DNA Topoisomerase
- DNA Nicking-Closing Protein
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases, Type I".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases, Type I".
This graph shows the total number of publications written about "DNA Topoisomerases, Type I" by people in this website by year, and whether "DNA Topoisomerases, Type I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Topoisomerases, Type I" by people in Profiles.
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RNA interacts with topoisomerase I to adjust DNA topology. Mol Cell. 2024 Sep 05; 84(17):3192-3208.e11.
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TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors. Pharmacol Res. 2021 11; 173:105911.
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Topoisomerase III-? is required for efficient replication of positive-sense RNA viruses. Antiviral Res. 2020 10; 182:104874.
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Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. J Med Chem. 2019 04 11; 62(7):3428-3446.
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TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase. Nucleic Acids Res. 2018 01 25; 46(2):861-872.
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Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. Nucleic Acids Res. 2017 Jun 02; 45(10):5850-5862.
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Mechanical bounds to transcriptional noise. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):13983-13988.
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Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell. 2014 Feb 06; 53(3):484-97.
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Selective transport of cationized fluorescent topoisomerase into nuclei of live cells for DNA damage studies. Methods Mol Biol. 2014; 1094:167-75.
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Top3? is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nat Neurosci. 2013 Sep; 16(9):1238-47.