"Werner Syndrome Helicase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
| Descriptor ID |
D000071657
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| MeSH Number(s) |
D08.811.277.040.025.159.249.500 D08.811.277.352.335.375.875 D08.811.277.352.365.290.500 D08.811.399.340.249.500 D12.776.157.687.750 D12.776.660.720.750
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| Concept/Terms |
Werner Syndrome Helicase- Werner Syndrome Helicase
- Helicase, Werner Syndrome
- Werner Syndrome ATP-Dependent Helicase
- Werner Syndrome ATP Dependent Helicase
- RECQL2 Protein
- Werner Syndrome RecQ-Like Helicase
- Werner Syndrome RecQ Like Helicase
- RECQ3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Werner Syndrome Helicase".
Below are MeSH descriptors whose meaning is more specific than "Werner Syndrome Helicase".
This graph shows the total number of publications written about "Werner Syndrome Helicase" by people in this website by year, and whether "Werner Syndrome Helicase" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Werner Syndrome Helicase" by people in Profiles.
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Werner syndrome through the lens of tissue and tumour genomics. Sci Rep. 2016 08 25; 6:32038.
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The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle. 2011 Jun 15; 10(12):1998-2007.
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The Werner's Syndrome RecQ helicase/exonuclease at the nexus of cancer and aging. Hawaii Med J. 2011 Mar; 70(3):52-5.
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Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy. Cancer Biol Ther. 2010 Sep 01; 10(5):430-7.
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Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. J Biol Chem. 2010 Aug 13; 285(33):25699-707.
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Ku's essential role in keeping telomeres intact. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12217-8.
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WRN at telomeres: implications for aging and cancer. J Cell Sci. 2007 Mar 01; 120(Pt 5):713-21.
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WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol. 2006 May; 13(5):414-22.
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Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 2005 Nov 01; 19(21):2560-70.
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The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. J Biol Chem. 2005 Dec 09; 280(49):40559-67.