"Werner Syndrome Helicase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
| Descriptor ID |
D000071657
|
| MeSH Number(s) |
D08.811.277.040.025.159.249.500 D08.811.277.352.335.375.875 D08.811.277.352.365.290.500 D08.811.399.340.249.500 D12.776.157.687.750 D12.776.660.720.750
|
| Concept/Terms |
Werner Syndrome Helicase- Werner Syndrome Helicase
- Helicase, Werner Syndrome
- Werner Syndrome ATP-Dependent Helicase
- Werner Syndrome ATP Dependent Helicase
- RECQL2 Protein
- Werner Syndrome RecQ-Like Helicase
- Werner Syndrome RecQ Like Helicase
- RECQ3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Werner Syndrome Helicase".
Below are MeSH descriptors whose meaning is more specific than "Werner Syndrome Helicase".
This graph shows the total number of publications written about "Werner Syndrome Helicase" by people in this website by year, and whether "Werner Syndrome Helicase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Werner Syndrome Helicase" by people in Profiles.
-
Ku's essential role in keeping telomeres intact. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12217-8.
-
The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. J Biol Chem. 2005 Dec 09; 280(49):40559-67.
-
An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum Genet. 1997 Dec; 101(2):121-5.