DNA-Activated Protein Kinase
"DNA-Activated Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR PROTEIN P53 and a variety of TRANSCRIPTION FACTORS.
| Descriptor ID |
D051747
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.250 D12.776.157.687.438 D12.776.660.720.438
|
| Concept/Terms |
DNA-Activated Protein Kinase- DNA-Activated Protein Kinase
- DNA Activated Protein Kinase
- Kinase, DNA-Activated Protein
- Protein Kinase, DNA-Activated
- DNA-Dependent Protein Serine-Threonine Kinase
- DNA Dependent Protein Serine Threonine Kinase
- DNA-Dependent Protein Kinase
- DNA Dependent Protein Kinase
- Kinase, DNA-Dependent Protein
- Protein Kinase, DNA-Dependent
|
Below are MeSH descriptors whose meaning is more general than "DNA-Activated Protein Kinase".
Below are MeSH descriptors whose meaning is more specific than "DNA-Activated Protein Kinase".
This graph shows the total number of publications written about "DNA-Activated Protein Kinase" by people in this website by year, and whether "DNA-Activated Protein Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 3 | 3 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 6 | 6 |
| 2006 | 2 | 0 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 3 | 0 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 2 | 4 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 2 | 3 |
| 2016 | 3 | 1 | 4 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "DNA-Activated Protein Kinase" by people in Profiles.
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EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma. Neuro Oncol. 2022 10 03; 24(10):1712-1725.
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DNA-PK Inhibition and Radiation Promote Antitumoral Immunity through RNA Polymerase III in Pancreatic Cancer. Mol Cancer Res. 2022 07 06; 20(7):1137-1150.
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Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy. Front Immunol. 2021; 12:797880.
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Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers. Int J Radiat Oncol Biol Phys. 2021 12 01; 111(5):e54-e62.
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DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia. Sci Rep. 2021 06 09; 11(1):12148.
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X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. Protein Sci. 2021 09; 30(9):1735-1756.
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Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Prog Biophys Mol Biol. 2021 08; 163:87-108.
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Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. Prog Biophys Mol Biol. 2021 08; 163:74-86.
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CRISPR-Cas9-mediated knockout of the Prkdc in mouse embryonic stem cells leads to the modulation of the expression of pluripotency genes. J Cell Physiol. 2020 04; 235(4):3994-4000.
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Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells. Biochem Biophys Res Commun. 2017 04 29; 486(2):307-313.