DNA-Activated Protein Kinase
"DNA-Activated Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR PROTEIN P53 and a variety of TRANSCRIPTION FACTORS.
| Descriptor ID |
D051747
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.250 D12.776.157.687.438 D12.776.660.720.438
|
| Concept/Terms |
DNA-Activated Protein Kinase- DNA-Activated Protein Kinase
- DNA Activated Protein Kinase
- Kinase, DNA-Activated Protein
- Protein Kinase, DNA-Activated
- DNA-Dependent Protein Serine-Threonine Kinase
- DNA Dependent Protein Serine Threonine Kinase
- DNA-Dependent Protein Kinase
- DNA Dependent Protein Kinase
- Kinase, DNA-Dependent Protein
- Protein Kinase, DNA-Dependent
|
Below are MeSH descriptors whose meaning is more general than "DNA-Activated Protein Kinase".
Below are MeSH descriptors whose meaning is more specific than "DNA-Activated Protein Kinase".
This graph shows the total number of publications written about "DNA-Activated Protein Kinase" by people in this website by year, and whether "DNA-Activated Protein Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA-Activated Protein Kinase" by people in Profiles.
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Genetic vulnerabilities upon inhibition of DNA damage response. Nucleic Acids Res. 2021 08 20; 49(14):8214-8231.
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Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Prog Biophys Mol Biol. 2021 08; 163:87-108.
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Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses. J Cell Physiol. 2021 02; 236(2):1195-1213.
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CRISPR-Cas9-mediated knockout of the Prkdc in mouse embryonic stem cells leads to the modulation of the expression of pluripotency genes. J Cell Physiol. 2020 04; 235(4):3994-4000.
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Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK. Mol Endocrinol. 2016 Feb; 30(2):158-72.
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Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25; 51(2):185-99.
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Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following ?-irradiation. J Biol Chem. 2013 Jul 19; 288(29):21376-21388.
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Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. J Biol Chem. 2012 Sep 07; 287(37):31015-26.
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DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIa inhibitor. Mol Pharmacol. 2011 Aug; 80(2):321-7.
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Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation. J Biol Chem. 2009 Mar 27; 284(13):8621-32.