"Centromere Protein A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
| Descriptor ID |
D000076247
|
| MeSH Number(s) |
D12.776.157.687.173 D12.776.260.123 D12.776.660.235.100 D12.776.660.720.173 D12.776.664.235.100 D23.050.422.031
|
| Concept/Terms |
Centromere Protein A- Centromere Protein A
- CENPA Protein
- Centromere Protein 17K
- CENP-A Protein
- CENP A Protein
- Centromere Autoantigens 17K
- Autoantigens 17K, Centromere
|
Below are MeSH descriptors whose meaning is more general than "Centromere Protein A".
Below are MeSH descriptors whose meaning is more specific than "Centromere Protein A".
This graph shows the total number of publications written about "Centromere Protein A" by people in this website by year, and whether "Centromere Protein A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Centromere Protein A" by people in Profiles.
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Spt6 is a maintenance factor for centromeric CENP-A. Nat Commun. 2020 06 10; 11(1):2919.
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Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation. J Cell Biol. 2018 06 04; 217(6):1957-1972.
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Plasticity and epigenetic inheritance of centromere-specific histone H3 (CENP-A)-containing nucleosome positioning in the fission yeast. J Biol Chem. 2013 Jun 28; 288(26):19184-96.
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Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr; 21(2):101-6.
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Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer. Breast Cancer Res. 2012 May 04; 14(3):R72.
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Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis. Cell Cycle. 2008 Mar 15; 7(6):787-95.
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Relevance of histone acetylation and replication timing for deposition of centromeric histone CENP-A. Exp Cell Res. 2003 May 01; 285(2):175-88.
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Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J Cell Sci. 2001 Oct; 114(Pt 19):3529-42.
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The mammalian centromere: structural domains and the attenuation of chromatin modeling. FASEB J. 1999 Dec; 13 Suppl 2:S216-20.
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Organization of centromeres in the decondensed nuclei of mature human sperm. Chromosoma. 1993 Sep; 102(8):509-18.