Xeroderma Pigmentosum Group A Protein
"Xeroderma Pigmentosum Group A Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ZINC FINGER MOTIF protein that recognizes and interacts with damaged DNA. It is a DNA-binding protein that plays an essential role in NUCLEOTIDE EXCISION REPAIR. Mutations in this protein are associated with the most severe form of XERODERMA PIGMENTOSUM.
| Descriptor ID |
D051760
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| MeSH Number(s) |
D12.776.157.687.875 D12.776.260.975 D12.776.660.720.875
|
| Concept/Terms |
Xeroderma Pigmentosum Group A Protein- Xeroderma Pigmentosum Group A Protein
- XPA Nucleotide Excision Repair Protein
- Xeroderma Pigmentosum-A Protein
- Xeroderma Pigmentosum A Protein
- XPA Repair Protein
- Xeroderma Pigmentosum Group A Complementing Protein
|
Below are MeSH descriptors whose meaning is more general than "Xeroderma Pigmentosum Group A Protein".
Below are MeSH descriptors whose meaning is more specific than "Xeroderma Pigmentosum Group A Protein".
This graph shows the total number of publications written about "Xeroderma Pigmentosum Group A Protein" by people in this website by year, and whether "Xeroderma Pigmentosum Group A Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1994 | 0 | 3 | 3 |
| 1995 | 0 | 4 | 4 |
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 3 | 3 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Xeroderma Pigmentosum Group A Protein" by people in Profiles.
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Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair. Nat Commun. 2024 Oct 01; 15(1):8511.
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Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2207408119.
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Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. Mol Carcinog. 2018 06; 57(6):784-793.
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Response to "XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage". DNA Repair (Amst). 2018 02; 62:30-31.
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Transcriptional consequences of XPA disruption in human cell lines. DNA Repair (Amst). 2017 09; 57:76-90.
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Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN. Mol Cell. 2016 11 17; 64(4):688-703.
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Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. Int J Cancer. 2013 Aug 01; 133(3):695-704.
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Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1. Hum Mol Genet. 2011 Dec 15; 20(24):4822-30.
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The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair. DNA Repair (Amst). 2010 Jul 01; 9(7):813-23.
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Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol. 2010 May; 130(5):1428-37.