"Ku Autoantigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.
| Descriptor ID |
D000072200
|
| MeSH Number(s) |
D08.811.277.040.025.159.155 D08.811.399.340.155 D12.776.157.687.493 D12.776.260.525 D12.776.660.625.625 D12.776.660.720.493 D23.050.290.625
|
| Concept/Terms |
Ku Autoantigen- Ku Autoantigen
- Autoantigen, Ku
- Ku Heterodimer
- Heterodimer, Ku
- Ku Protein
- Ku Antigen
- Antigen, Ku
- G22P1 Antigen
- Antigen, G22P1
Ku80 Antigen- Ku80 Antigen
- Antigen, Ku80
- Ku Autoantigen, 80 kDa
- XRCC5 Protein
- X-ray Repair Cross-Complementing Protein 5
- X ray Repair Cross Complementing Protein 5
Ku70 Antigen- Ku70 Antigen
- Antigen, Ku70
- Ku Autoantigen, 70 kDa
- XRCC6 Protein
- X-ray Repair Cross-Complementing Protein 6
- X ray Repair Cross Complementing Protein 6
|
Below are MeSH descriptors whose meaning is more general than "Ku Autoantigen".
Below are MeSH descriptors whose meaning is more specific than "Ku Autoantigen".
This graph shows the total number of publications written about "Ku Autoantigen" by people in this website by year, and whether "Ku Autoantigen" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 4 | 4 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 5 | 5 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 5 | 5 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ku Autoantigen" by people in Profiles.
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X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. Protein Sci. 2021 09; 30(9):1735-1756.
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Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids Res. 2020 11 04; 48(19):10953-10972.
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Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. Prog Biophys Mol Biol. 2021 08; 163:74-86.
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Noncanonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis. Am J Physiol Lung Cell Mol Physiol. 2020 10 01; 319(4):L728-L741.
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Dissection of DNA double-strand-break repair using novel single-molecule forceps. Nat Struct Mol Biol. 2018 06; 25(6):482-487.
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Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae. Genetics. 2018 05; 209(1):115-128.
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An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex. J Biol Chem. 2016 12 30; 291(53):26987-27006.
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Bax-induced apoptosis shortens the life span of DNA repair defect Ku70-knockout mice by inducing emphysema. Exp Biol Med (Maywood). 2016 06; 241(12):1265-71.
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Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases. Cell Death Dis. 2015 Mar 26; 6:e1706.
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Transcriptional regulation of the sodium-coupled neutral amino acid transporter (SNAT2) by 17?-estradiol. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11443-8.