"Telomere Shortening" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS.) Telomere shortening is involved in the progression of CELL AGING.
| Descriptor ID |
D059506
|
| MeSH Number(s) |
G02.111.225.940 G04.043.630 G05.226.940
|
| Concept/Terms |
Telomere Shortening- Telomere Shortening
- Shortening, Telomere
- Shortenings, Telomere
- Telomere Shortenings
|
Below are MeSH descriptors whose meaning is more general than "Telomere Shortening".
Below are MeSH descriptors whose meaning is more specific than "Telomere Shortening".
This graph shows the total number of publications written about "Telomere Shortening" by people in this website by year, and whether "Telomere Shortening" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 3 | 4 |
| 2019 | 2 | 1 | 3 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 1 | 2 |
| 2024 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Telomere Shortening" by people in Profiles.
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Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis. Nat Genet. 2025 Sep; 57(9):2215-2225.
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Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease. Thorax. 2024 01 18; 79(2):182-185.
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Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita. Blood. 2022 08 11; 140(6):608-618.
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Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue. Blood. 2022 02 17; 139(7):1039-1051.
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Hematopoiesis under telomere attrition at the single-cell resolution. Nat Commun. 2021 11 25; 12(1):6850.
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Short NK- and Na?ve T-Cell Telomere Length Is Associated with Thyroid Cancer in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):453-460.
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From incomplete penetrance with normal telomere length to severe disease and telomere shortening in a family with monoallelic and biallelic PARN pathogenic variants. Hum Mutat. 2019 12; 40(12):2414-2429.
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Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres. Pediatr Blood Cancer. 2019 08; 66(8):e27779.
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Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019 06 04; 29(6):1274-1290.e9.
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The Future of Onco-Cardiology: We Are Not Just "Side Effect Hunters". Circ Res. 2016 09 30; 119(8):896-9.