"Telomere Shortening" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS.) Telomere shortening is involved in the progression of CELL AGING.
| Descriptor ID |
D059506
|
| MeSH Number(s) |
G02.111.225.940 G04.043.630 G05.226.940
|
| Concept/Terms |
Telomere Shortening- Telomere Shortening
- Shortening, Telomere
- Shortenings, Telomere
- Telomere Shortenings
|
Below are MeSH descriptors whose meaning is more general than "Telomere Shortening".
Below are MeSH descriptors whose meaning is more specific than "Telomere Shortening".
This graph shows the total number of publications written about "Telomere Shortening" by people in this website by year, and whether "Telomere Shortening" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2019 | 2 | 1 | 3 |
| 2020 | 1 | 0 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 1 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Telomere Shortening" by people in Profiles.
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Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease. Thorax. 2024 01 18; 79(2):182-185.
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TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo. Neuro Oncol. 2022 12 01; 24(12):2063-2075.
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A promising preclinical model for TERT promoter mutation in glioblastoma. Neuro Oncol. 2022 12 01; 24(12):2076-2077.
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Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita. Blood. 2022 08 11; 140(6):608-618.
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Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue. Blood. 2022 02 17; 139(7):1039-1051.
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Hematopoiesis under telomere attrition at the single-cell resolution. Nat Commun. 2021 11 25; 12(1):6850.
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Short NK- and Na?ve T-Cell Telomere Length Is Associated with Thyroid Cancer in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):453-460.
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Programmable base editing of mutated TERT promoter inhibits brain tumour growth. Nat Cell Biol. 2020 03; 22(3):282-288.
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Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications. Neurosci Biobehav Rev. 2020 05; 112:107-116.
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From incomplete penetrance with normal telomere length to severe disease and telomere shortening in a family with monoallelic and biallelic PARN pathogenic variants. Hum Mutat. 2019 12; 40(12):2414-2429.