"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
| Descriptor ID |
D018095
|
| MeSH Number(s) |
G05.365.590.350
|
| Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 3 | 6 |
| 1995 | 2 | 3 | 5 |
| 1996 | 3 | 3 | 6 |
| 1997 | 2 | 1 | 3 |
| 1998 | 6 | 2 | 8 |
| 1999 | 6 | 6 | 12 |
| 2000 | 5 | 2 | 7 |
| 2001 | 3 | 3 | 6 |
| 2002 | 6 | 8 | 14 |
| 2003 | 5 | 4 | 9 |
| 2004 | 7 | 4 | 11 |
| 2005 | 5 | 5 | 10 |
| 2006 | 3 | 4 | 7 |
| 2007 | 3 | 10 | 13 |
| 2008 | 5 | 5 | 10 |
| 2009 | 3 | 7 | 10 |
| 2010 | 8 | 12 | 20 |
| 2011 | 6 | 10 | 16 |
| 2012 | 4 | 9 | 13 |
| 2013 | 6 | 9 | 15 |
| 2014 | 18 | 10 | 28 |
| 2015 | 12 | 8 | 20 |
| 2016 | 13 | 15 | 28 |
| 2017 | 13 | 28 | 41 |
| 2018 | 10 | 20 | 30 |
| 2019 | 12 | 20 | 32 |
| 2020 | 19 | 17 | 36 |
| 2021 | 9 | 19 | 28 |
| 2022 | 2 | 21 | 23 |
| 2023 | 1 | 14 | 15 |
| 2024 | 15 | 11 | 26 |
To return to the timeline,
click here.
Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
-
SDHB-Associated Pheochromocytomas: What is Their Clinical Behavior? Ann Surg Oncol. 2024 Dec; 31(13):9007-9013.
-
Germline mutations in a G protein identify signaling cross-talk in T cells. Science. 2024 Sep 20; 385(6715):eadd8947.
-
Evaluation of Bayesian point-based system on the variant classification of hereditary cancer predisposition genes. Genet Med. 2024 Dec; 26(12):101276.
-
Comparing the Diagnostic Yield of Germline Exome Versus Panel Sequencing in the Diverse Population of the Texas KidsCanSeq Pediatric Cancer Study. JCO Precis Oncol. 2024 Sep; 8:e2400187.
-
BRCA-mutated breast cancer: the unmet need, challenges and therapeutic benefits of genetic testing. Br J Cancer. 2024 Nov; 131(9):1400-1414.
-
A comprehensive study evaluating germline FANCG variants in predisposition to breast and ovarian cancer. Cancer Med. 2024 Aug; 13(16):e70103.
-
TP53-associated early breast cancer: new observations from a large cohort. J Natl Cancer Inst. 2024 Aug 01; 116(8):1246-1254.
-
Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial. Oncologist. 2024 Jul 05; 29(7):638-e952.
-
Germline Testing Identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors. Cancer Prev Res (Phila). 2024 Jul 02; 17(7):335-342.
-
Implementation, Evolution, and Laboratory Performance of Methods-Based Proficiency Testing for Next-Generation Sequencing Detection of Germline Sequence Variants. Arch Pathol Lab Med. 2024 Jul 01; 148(7):775-783.