"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
| Descriptor ID |
D018095
|
| MeSH Number(s) |
G05.365.590.350
|
| Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 3 | 6 |
| 1995 | 1 | 3 | 4 |
| 1996 | 3 | 2 | 5 |
| 1997 | 3 | 1 | 4 |
| 1998 | 6 | 2 | 8 |
| 1999 | 6 | 5 | 11 |
| 2000 | 5 | 2 | 7 |
| 2001 | 3 | 2 | 5 |
| 2002 | 4 | 5 | 9 |
| 2003 | 6 | 4 | 10 |
| 2004 | 6 | 4 | 10 |
| 2005 | 7 | 4 | 11 |
| 2006 | 3 | 5 | 8 |
| 2007 | 3 | 10 | 13 |
| 2008 | 4 | 5 | 9 |
| 2009 | 3 | 8 | 11 |
| 2010 | 7 | 12 | 19 |
| 2011 | 6 | 11 | 17 |
| 2012 | 4 | 9 | 13 |
| 2013 | 6 | 9 | 15 |
| 2014 | 18 | 10 | 28 |
| 2015 | 12 | 8 | 20 |
| 2016 | 13 | 15 | 28 |
| 2017 | 13 | 29 | 42 |
| 2018 | 12 | 22 | 34 |
| 2019 | 12 | 19 | 31 |
| 2020 | 19 | 17 | 36 |
| 2021 | 9 | 17 | 26 |
| 2022 | 2 | 21 | 23 |
| 2023 | 1 | 14 | 15 |
| 2024 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
-
LFSPROShiny: An Interactive R/Shiny App for Prediction and Visualization of Cancer Risks in Families With Deleterious Germline TP53 Mutations. JCO Clin Cancer Inform. 2024 Feb; 8:e2300167.
-
Germline Testing in Patients With Breast Cancer: ASCO-Society of Surgical Oncology Guideline. J Clin Oncol. 2024 Feb 10; 42(5):584-604.
-
Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement. Nat Rev Endocrinol. 2024 Mar; 20(3):168-184.
-
Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41. Blood Adv. 2023 10 24; 7(20):6092-6107.
-
Gene-specific ACMG/AMP classification criteria for germline APC variants: Recommendations from the ClinGen InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel. Genet Med. 2024 Feb; 26(2):100992.
-
Neoadjuvant Talazoparib in Patients With Germline BRCA1/2 Mutation-Positive, Early-Stage Triple-Negative Breast Cancer: Results of a Phase II Study. Oncologist. 2023 10 03; 28(10):845-855.
-
NCCN Guidelines? Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024. J Natl Compr Canc Netw. 2023 10; 21(10):1000-1010.
-
ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk. Clin Cancer Res. 2023 08 15; 29(16):3037-3050.
-
Constitutional balanced translocations involving SMARCB1: A rare cause of rhabdoid tumor predisposition syndrome. Genes Chromosomes Cancer. 2024 Jan; 63(1):e23195.
-
Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors. JCO Precis Oncol. 2023 08; 7:e2300070.