"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
| Descriptor ID |
D018095
|
| MeSH Number(s) |
G05.365.590.350
|
| Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 0 | 2 |
| 1999 | 2 | 2 | 4 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2003 | 3 | 2 | 5 |
| 2004 | 3 | 0 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 3 | 4 |
| 2008 | 4 | 3 | 7 |
| 2009 | 2 | 1 | 3 |
| 2010 | 2 | 2 | 4 |
| 2011 | 3 | 1 | 4 |
| 2012 | 0 | 4 | 4 |
| 2013 | 1 | 2 | 3 |
| 2014 | 12 | 4 | 16 |
| 2015 | 6 | 5 | 11 |
| 2016 | 9 | 6 | 15 |
| 2017 | 9 | 7 | 16 |
| 2018 | 5 | 8 | 13 |
| 2019 | 2 | 13 | 15 |
| 2020 | 8 | 5 | 13 |
| 2021 | 4 | 6 | 10 |
| 2022 | 2 | 11 | 13 |
| 2023 | 1 | 4 | 5 |
| 2024 | 8 | 2 | 10 |
| 2025 | 9 | 9 | 18 |
| 2026 | 0 | 3 | 3 |
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click here.
Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
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Integrated Spatial Analysis Reveals the Molecular Landscape of Ovarian Precancerous Lesions. Cancer Res. 2026 Apr 02; 86(7):1739-1752.
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DICER1-mutated renal neoplasia: A series of 5 cases demonstrating the spectrum of cystic nephroma, Wilms tumor, and anaplastic sarcoma. Hum Pathol. 2026 Jun; 172:106110.
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Tuberous sclerosis complex-associated renal cell carcinoma, an underappreciated form of familial renal cancer, is characterized by activation of the TFEB/TFE3 pathway. Hum Mol Genet. 2026 Feb 08; 35(1).
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Clinical Trial in Progress: SWOG S2210, a Phase 2 Study of Neoadjuvant Carboplatin for Localized High-risk Prostate Cancer with Germline BRCA1/2 Mutations. Eur Urol Focus. 2026 Jan; 12(1):16-18.
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Germline Cancer Predisposition Results From the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial. JCO Precis Oncol. 2025 Oct; 9:e2500742.
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A quantitative, Bayesian-informed approach to gene-specific variant classification: Updated Expert Panel recommendations improve classification of TP53 germline variants for Li-Fraumeni syndrome. Genome Med. 2025 10 22; 17(1):128.
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Exploration of possible association of BRIP1 pathogenic variants with central nervous system cancers in an institutional cohort. J Med Genet. 2025 Oct 20; 62(11):720-723.
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Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations. Nat Commun. 2025 Oct 16; 16(1):9194.
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Germline structural variations involving the pediatric brain tumor transcriptome include disease-relevant and ancestry-related genes. Acta Neuropathol Commun. 2025 Aug 20; 13(1):179.
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Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study. J Clin Oncol. 2025 Sep 20; 43(27):3011-3020.