Synthetic Lethal Mutations
"Synthetic Lethal Mutations" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mutations in genes which lead to cell or organism death when occurring in combination with mutations in one or more other genes.
| Descriptor ID |
D000072020
|
| MeSH Number(s) |
G05.365.590.917
|
| Concept/Terms |
Synthetic Lethal Mutations- Synthetic Lethal Mutations
- Synthetic Lethal Mutation
- Lethal Mutation, Synthetic
- Lethal Mutations, Synthetic
- Mutation, Synthetic Lethal
- Mutations, Synthetic Lethal
|
Below are MeSH descriptors whose meaning is more general than "Synthetic Lethal Mutations".
Below are MeSH descriptors whose meaning is more specific than "Synthetic Lethal Mutations".
This graph shows the total number of publications written about "Synthetic Lethal Mutations" by people in this website by year, and whether "Synthetic Lethal Mutations" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Synthetic Lethal Mutations" by people in Profiles.
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SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells. Elife. 2024 Jun 18; 12.
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Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy. Life Sci Alliance. 2024 04; 7(4).
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DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023 10 16; 3(10):2096-2112.
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DNA polymerase ? compensates for Fanconi anemia pathway deficiency by countering DNA replication stress. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33436-33445.
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CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas. Leukemia. 2020 12; 34(12):3269-3285.
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Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019 06 10; 35(6):868-884.e6.
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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 03 07; 73(5):885-899.e6.
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Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 01 08; 26(2):469-482.e5.
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Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis. Cancer Res. 2019 01 01; 79(1):125-132.
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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Cancer Cell. 2017 Dec 11; 32(6):748-760.e6.