"MutL Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.
| Descriptor ID |
D000070956
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| MeSH Number(s) |
D08.811.074.766 D08.811.277.040.025.215 D12.776.260.540
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "MutL Proteins".
Below are MeSH descriptors whose meaning is more specific than "MutL Proteins".
This graph shows the total number of publications written about "MutL Proteins" by people in this website by year, and whether "MutL Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1997 | 0 | 4 | 4 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "MutL Proteins" by people in Profiles.
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Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer. Nat Commun. 2021 05 19; 12(1):2940.
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Binding of the regulatory domain of MutL to the sliding ?-clamp is species specific. Nucleic Acids Res. 2019 05 21; 47(9):4831-4842.
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The endonuclease domain of Bacillus subtilis MutL is functionally asymmetric. DNA Repair (Amst). 2019 01; 73:1-6.
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Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer. Cancer Discov. 2017 10; 7(10):1168-1183.
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The sliding clamp tethers the endonuclease domain of MutL to DNA. Nucleic Acids Res. 2015 Dec 15; 43(22):10746-59.
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DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17308-13.
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Characterization of the defects in the ATP lid of E. coli MutL that cause transient hypermutability. DNA Repair (Amst). 2013 Oct; 12(10):864-9.
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The endonuclease domain of MutL interacts with the ? sliding clamp. DNA Repair (Amst). 2011 Jan 02; 10(1):87-93.
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Functional residues on the surface of the N-terminal domain of yeast Pms1. DNA Repair (Amst). 2010 Apr 04; 9(4):448-57.
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ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol. 2004 Jul; 24(14):6430-44.