"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Descriptor ID |
D004249
|
MeSH Number(s) |
G05.200
|
Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
|
Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 4 | 16 | 20 |
1995 | 6 | 13 | 19 |
1996 | 10 | 10 | 20 |
1997 | 6 | 12 | 18 |
1998 | 7 | 11 | 18 |
1999 | 18 | 11 | 29 |
2000 | 12 | 13 | 25 |
2001 | 17 | 13 | 30 |
2002 | 14 | 16 | 30 |
2003 | 26 | 29 | 55 |
2004 | 24 | 30 | 54 |
2005 | 26 | 25 | 51 |
2006 | 27 | 27 | 54 |
2007 | 23 | 22 | 45 |
2008 | 23 | 21 | 44 |
2009 | 22 | 31 | 53 |
2010 | 19 | 44 | 63 |
2011 | 17 | 37 | 54 |
2012 | 16 | 30 | 46 |
2013 | 16 | 33 | 49 |
2014 | 18 | 27 | 45 |
2015 | 18 | 30 | 48 |
2016 | 13 | 26 | 39 |
2017 | 23 | 27 | 50 |
2018 | 14 | 19 | 33 |
2019 | 13 | 22 | 35 |
2020 | 13 | 25 | 38 |
2021 | 14 | 21 | 35 |
2022 | 1 | 14 | 15 |
2023 | 2 | 15 | 17 |
2024 | 0 | 3 | 3 |
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Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Targeting ATR in patients with cancer. Nat Rev Clin Oncol. 2024 Apr; 21(4):278-293.
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Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma. Nat Commun. 2024 Feb 08; 15(1):1203.
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GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress. Cancer Discov. 2024 01 12; 14(1):158-175.
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Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension. Nat Commun. 2023 Nov 21; 14(1):7578.
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SETD2 Loss and ATR Inhibition Synergize to Promote cGAS Signaling and Immunotherapy Response in Renal Cell Carcinoma. Clin Cancer Res. 2023 10 02; 29(19):4002-4015.
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TGF? signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells. Cell Mol Life Sci. 2023 Sep 09; 80(10):288.
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Implications of Translesion DNA Synthesis Polymerases on Genomic Stability and Human Health. Mol Cell Biol. 2023; 43(8):401-425.
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Spatial mapping of the DNA adducts in cancer. DNA Repair (Amst). 2023 08; 128:103529.
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Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage. Cell Death Dis. 2023 06 23; 14(6):371.
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Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. Nat Med. 2023 Jun; 29(6):1400-1411.