"DNA Fragmentation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.
| Descriptor ID |
D053938
|
| MeSH Number(s) |
G05.200.230
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "DNA Fragmentation".
Below are MeSH descriptors whose meaning is more specific than "DNA Fragmentation".
This graph shows the total number of publications written about "DNA Fragmentation" by people in this website by year, and whether "DNA Fragmentation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 6 | 6 |
| 1999 | 0 | 6 | 6 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 1 | 1 |
| 2002 | 3 | 3 | 6 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 3 | 4 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 3 | 3 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "DNA Fragmentation" by people in Profiles.
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What is the role of varicocelectomy in infertile men with clinical varicoceles and elevated sperm DNA fragmentation? Fertil Steril. 2021 09; 116(3):657-658.
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Elevated sperm DNA fragmentation does not predict recurrent implantation failure. Andrologia. 2021 Aug; 53(7):e14094.
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Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect. Reprod Sci. 2021 07; 28(7):1850-1865.
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Use of testicular sperm to combat the negative effects of DNA fragmentation. Asian J Androl. 2016 May-Jun; 18(3):434.
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Fluorescence in situ hybridization detects increased sperm aneuploidy in men with recurrent pregnancy loss. Fertil Steril. 2015 Apr; 103(4):906-909.e1.
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The office visit. Urol Clin North Am. 2014 Feb; 41(1):19-37.
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C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. PLoS One. 2013; 8(9):e74768.
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Bis-(2-ethylexhyl) phthalate impairs spermatogenesis in zebrafish (Danio rerio). Reprod Biol. 2013 Sep; 13(3):195-202.
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Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem. 2013 Feb 01; 288(5):3460-8.
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Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol Pharmacol. 2012 Dec; 82(6):1162-73.