"Founder Effect" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
| Descriptor ID |
D018703
|
| MeSH Number(s) |
G05.285
|
| Concept/Terms |
Founder Effect- Founder Effect
- Effect, Founder
- Effects, Founder
- Founder Effects
|
Below are MeSH descriptors whose meaning is more general than "Founder Effect".
Below are MeSH descriptors whose meaning is more specific than "Founder Effect".
This graph shows the total number of publications written about "Founder Effect" by people in this website by year, and whether "Founder Effect" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 2 | 1 | 3 |
| 2001 | 0 | 3 | 3 |
| 2003 | 3 | 1 | 4 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 3 | 0 | 3 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Founder Effect" by people in Profiles.
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Founder Effects of Spinocerebellar Ataxias in the American Continents and the Caribbean. Cerebellum. 2020 Jun; 19(3):446-458.
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Functional biology of the Steel syndrome founder allele and evidence for clan genomics derivation of COL27A1 pathogenic alleles worldwide. Eur J Hum Genet. 2020 09; 28(9):1243-1264.
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Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9. Sci Rep. 2016 Sep 02; 6:32565.
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A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. PLoS Genet. 2016 Apr; 12(4):e1005848.
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How Obstacles Perturb Population Fronts and Alter Their Genetic Structure. PLoS Comput Biol. 2015 Dec; 11(12):e1004615.
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Mutations in COL27A1 cause Steel syndrome and suggest a founder mutation effect in the Puerto Rican population. Eur J Hum Genet. 2015 Mar; 23(3):342-6.
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Congenital nephrotic syndrome with prolonged renal survival without renal replacement therapy. Pediatr Nephrol. 2013 Dec; 28(12):2313-21.
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Tracing synaptic connectivity onto embryonic stem cell-derived neurons. Stem Cells. 2012 Oct; 30(10):2140-51.
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Genomic analysis of pediatric cataract in Saudi Arabia reveals novel candidate disease genes. Genet Med. 2012 Dec; 14(12):955-62.
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Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations. Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19; 367(1590):820-9.