"DNA Repair" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
| Descriptor ID |
D004260
|
| MeSH Number(s) |
G02.111.222 G05.219
|
| Concept/Terms |
Base Excision Repair- Base Excision Repair
- Base Excision Repairs
- Excision Repair, Base
- Repair, Base Excision
- Repairs, Base Excision
|
Below are MeSH descriptors whose meaning is more general than "DNA Repair".
Below are MeSH descriptors whose meaning is more specific than "DNA Repair".
This graph shows the total number of publications written about "DNA Repair" by people in this website by year, and whether "DNA Repair" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 2 | 4 |
| 1997 | 4 | 4 | 8 |
| 1998 | 3 | 2 | 5 |
| 1999 | 4 | 1 | 5 |
| 2000 | 5 | 4 | 9 |
| 2001 | 2 | 1 | 3 |
| 2002 | 6 | 6 | 12 |
| 2003 | 8 | 5 | 13 |
| 2004 | 8 | 10 | 18 |
| 2005 | 10 | 7 | 17 |
| 2006 | 1 | 6 | 7 |
| 2007 | 7 | 10 | 17 |
| 2008 | 6 | 7 | 13 |
| 2009 | 4 | 4 | 8 |
| 2010 | 16 | 10 | 26 |
| 2011 | 6 | 7 | 13 |
| 2012 | 7 | 8 | 15 |
| 2013 | 7 | 6 | 13 |
| 2014 | 8 | 7 | 15 |
| 2015 | 16 | 12 | 28 |
| 2016 | 3 | 11 | 14 |
| 2017 | 11 | 10 | 21 |
| 2018 | 8 | 10 | 18 |
| 2019 | 5 | 8 | 13 |
| 2020 | 5 | 8 | 13 |
| 2021 | 8 | 9 | 17 |
| 2022 | 4 | 6 | 10 |
| 2023 | 0 | 9 | 9 |
| 2024 | 3 | 1 | 4 |
| 2025 | 0 | 3 | 3 |
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Below are the most recent publications written about "DNA Repair" by people in Profiles.
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Targeting FZD6 creates therapeutically actionable vulnerabilities for advanced prostate cancer. Oncogene. 2025 Dec; 44(50):4868-4877.
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PARP inhibitor response is enhanced in prostate cancer when XRCC1 expression is reduced. NAR Cancer. 2025 Jun; 7(2):zcaf015.
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In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene. Sci Transl Med. 2025 Feb 12; 17(785):eadk3920.
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Chemoproteogenomic stratification of the missense variant cysteinome. Nat Commun. 2024 10 28; 15(1):9284.
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Gene discovery from microbial gene libraries I: protection against reactive oxygen species-driven DNA damage. Microbiol Spectr. 2024 Nov 05; 12(11):e0036524.
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Systematic investigation of BRCA1-A, -B, and -C complexes and their functions in DNA damage response and DNA repair. Oncogene. 2024 08; 43(35):2621-2634.
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Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial. Oncologist. 2024 Jul 05; 29(7):638-e952.
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RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons. Sci Adv. 2023 12 08; 9(49):eadi6681.
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Life, the genome and everything. J Bacteriol. 2023 12 19; 205(12):e0027223.
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SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Cell Stem Cell. 2023 11 02; 30(11):1503-1519.e8.