"Allosteric Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.
| Descriptor ID |
D000494
|
| MeSH Number(s) |
G02.111.044
|
| Concept/Terms |
Allosteric Regulation- Allosteric Regulation
- Regulation, Allosteric
- Allosteric Regulations
- Regulations, Allosteric
|
Below are MeSH descriptors whose meaning is more general than "Allosteric Regulation".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Regulation".
This graph shows the total number of publications written about "Allosteric Regulation" by people in this website by year, and whether "Allosteric Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 3 | 4 |
| 2011 | 0 | 1 | 1 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 3 | 4 |
| 2015 | 0 | 4 | 4 |
| 2016 | 0 | 3 | 3 |
| 2017 | 0 | 4 | 4 |
| 2018 | 2 | 2 | 4 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 6 | 6 |
| 2021 | 0 | 4 | 4 |
| 2024 | 0 | 2 | 2 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Allosteric Regulation" by people in Profiles.
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PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins. Proc Natl Acad Sci U S A. 2025 Feb 25; 122(8):e2420961122.
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Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology. Mol Pharmacol. 2024 Feb 15; 105(3):260-271.
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Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor. Nature. 2024 Feb; 626(8001):1141-1148.
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In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution. Structure. 2022 01 06; 30(1):107-113.e3.
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Dynamical Basis of Allosteric Activation for the Plasmodium falciparum Protein Kinase G. J Phys Chem B. 2021 06 24; 125(24):6532-6542.
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Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J Med Chem. 2021 03 11; 64(5):2777-2800.
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Development of Allosteric Modulators of Voltage-Gated Na+ Channels: A Novel Approach for an Old Target. Curr Top Med Chem. 2021; 21(10):841-848.
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Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 01 01; 31:127696.
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An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes. J Immunol. 2020 11 15; 205(10):2806-2820.
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Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics. Molecules. 2020 Jul 24; 25(15).