"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
|
| MeSH Number(s) |
G02.111.905 G05.308.850 G07.690.773.998
|
| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 5 | 5 |
| 1995 | 1 | 6 | 7 |
| 1996 | 0 | 9 | 9 |
| 1997 | 1 | 11 | 12 |
| 1998 | 2 | 12 | 14 |
| 1999 | 3 | 15 | 18 |
| 2000 | 2 | 17 | 19 |
| 2001 | 1 | 35 | 36 |
| 2002 | 5 | 46 | 51 |
| 2003 | 5 | 74 | 79 |
| 2004 | 6 | 74 | 80 |
| 2005 | 6 | 80 | 86 |
| 2006 | 7 | 64 | 71 |
| 2007 | 5 | 45 | 50 |
| 2008 | 5 | 69 | 74 |
| 2009 | 6 | 78 | 84 |
| 2010 | 6 | 63 | 69 |
| 2011 | 11 | 81 | 92 |
| 2012 | 9 | 70 | 79 |
| 2013 | 9 | 60 | 69 |
| 2014 | 8 | 65 | 73 |
| 2015 | 8 | 41 | 49 |
| 2016 | 5 | 40 | 45 |
| 2017 | 8 | 42 | 50 |
| 2018 | 8 | 47 | 55 |
| 2019 | 2 | 49 | 51 |
| 2020 | 5 | 39 | 44 |
| 2021 | 5 | 23 | 28 |
| 2022 | 2 | 7 | 9 |
| 2023 | 0 | 9 | 9 |
| 2024 | 1 | 4 | 5 |
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Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NF?B. J Muscle Res Cell Motil. 2024 Dec; 45(4):191-200.
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AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12; 134(8):1006-1022.
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BTN1A1 is a novel immune checkpoint mutually exclusive to PD-L1. J Immunother Cancer. 2024 Mar 14; 12(3).
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Differential Upregulation of Th1/Th17-Associated Proteins and PD-L1 in Granulomatous Mycosis Fungoides. Cells. 2024 Feb 27; 13(5).
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Unveiling promising breast cancer biomarkers: an integrative approach combining bioinformatics analysis and experimental verification. BMC Cancer. 2024 Jan 31; 24(1):155.
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RNA-based translation activators for targeted gene upregulation. Nat Commun. 2023 10 26; 14(1):6827.
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Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity. Cell Rep. 2023 10 31; 42(10):113224.
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Increased interleukin-6/C-reactive protein levels are associated with the upregulation of the adenosine pathway and serve as potential markers of therapeutic resistance to immune checkpoint inhibitor-based therapies in non-small cell lung cancer. J Immunother Cancer. 2023 10; 11(10).
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METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury. Clin Transl Med. 2023 09; 13(9):e1389.
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Acute myeloid leukemias with JAK2/STAT mutations are associated with PD-L1 upregulation. Leuk Lymphoma. 2023 10; 64(10):1662-1672.