"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
| Descriptor ID |
D059748
|
| MeSH Number(s) |
G02.111.720 G03.812
|
| Concept/Terms |
Proteolysis- Proteolysis
- Proteolyses
- Protein Degradation
- Degradation, Protein
- Degradations, Protein
- Protein Degradations
Protein Digestion- Protein Digestion
- Digestion, Protein
- Digestions, Protein
- Protein Digestions
|
Below are MeSH descriptors whose meaning is more general than "Proteolysis".
Below are MeSH descriptors whose meaning is more specific than "Proteolysis".
This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 3 | 3 | 6 |
| 2012 | 2 | 2 | 4 |
| 2013 | 3 | 6 | 9 |
| 2014 | 8 | 12 | 20 |
| 2015 | 3 | 10 | 13 |
| 2016 | 1 | 7 | 8 |
| 2017 | 0 | 14 | 14 |
| 2018 | 0 | 6 | 6 |
| 2019 | 0 | 3 | 3 |
| 2020 | 6 | 7 | 13 |
| 2021 | 2 | 4 | 6 |
| 2022 | 0 | 3 | 3 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 3 | 3 |
| 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Proteolysis" by people in Profiles.
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MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation. ACS Chem Biol. 2025 Apr 18; 20(4):896-906.
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The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis. Cell Mol Life Sci. 2025 Mar 12; 82(1):107.
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Lasalocid A selectively induces the degradation of MYD88 in lymphomas harboring the MYD88 L265P mutation. Blood. 2025 Mar 06; 145(10):1047-1060.
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Targeting Oncogenic RET Kinase by Simultaneously Inhibiting Kinase Activity and Degrading the Protein. J Med Chem. 2025 01 09; 68(1):81-94.
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Development of a RIPK1 degrader to enhance antitumor immunity. Nat Commun. 2024 12 16; 15(1):10683.
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Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues. Eur J Med Chem. 2024 Dec 05; 279:116904.
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Template-assisted covalent modification underlies activity of covalent molecular glues. Nat Chem Biol. 2024 12; 20(12):1640-1649.
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Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction. J Mol Cell Cardiol. 2024 Sep; 194:85-95.
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Degradation trumps mutations in cancer. Science. 2024 02 02; 383(6682):480-481.
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Cell jamming in a collagen-based interface assay is tuned by collagen density and proteolysis. J Cell Sci. 2023 12 01; 136(23).