"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
| Descriptor ID |
D059748
|
| MeSH Number(s) |
G02.111.720 G03.812
|
| Concept/Terms |
Proteolysis- Proteolysis
- Proteolyses
- Protein Degradation
- Degradation, Protein
- Degradations, Protein
- Protein Degradations
Protein Digestion- Protein Digestion
- Digestion, Protein
- Digestions, Protein
- Protein Digestions
|
Below are MeSH descriptors whose meaning is more general than "Proteolysis".
Below are MeSH descriptors whose meaning is more specific than "Proteolysis".
This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 2 | 3 | 5 |
| 2012 | 2 | 2 | 4 |
| 2013 | 3 | 6 | 9 |
| 2014 | 9 | 13 | 22 |
| 2015 | 2 | 11 | 13 |
| 2016 | 1 | 6 | 7 |
| 2017 | 0 | 16 | 16 |
| 2018 | 0 | 7 | 7 |
| 2019 | 0 | 4 | 4 |
| 2020 | 6 | 9 | 15 |
| 2021 | 2 | 4 | 6 |
| 2022 | 0 | 2 | 2 |
| 2023 | 1 | 1 | 2 |
| 2024 | 0 | 4 | 4 |
| 2025 | 2 | 4 | 6 |
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Below are the most recent publications written about "Proteolysis" by people in Profiles.
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Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Science. 2026 Jan 08; 391(6781):195-201.
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Design, Optimization, and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties. J Med Chem. 2025 Nov 13; 68(21):22246-22263.
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A lysosomal surveillance response to stress extends healthspan. Nat Cell Biol. 2025 Jul; 27(7):1083-1097.
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MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation. ACS Chem Biol. 2025 Apr 18; 20(4):896-906.
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The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis. Cell Mol Life Sci. 2025 Mar 12; 82(1):107.
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Lasalocid A selectively induces the degradation of MYD88 in lymphomas harboring the MYD88 L265P mutation. Blood. 2025 Mar 06; 145(10):1047-1060.
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Targeting Oncogenic RET Kinase by Simultaneously Inhibiting Kinase Activity and Degrading the Protein. J Med Chem. 2025 01 09; 68(1):81-94.
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Development of a RIPK1 degrader to enhance antitumor immunity. Nat Commun. 2024 12 16; 15(1):10683.
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Targeting Ikaros and Aiolos: reviewing novel protein degraders for the treatment of multiple myeloma, with a focus on iberdomide and mezigdomide. Expert Rev Hematol. 2024 Aug; 17(8):445-465.
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Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction. J Mol Cell Cardiol. 2024 Sep; 194:85-95.