"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
| Descriptor ID |
D059748
|
| MeSH Number(s) |
G02.111.720 G03.812
|
| Concept/Terms |
Proteolysis- Proteolysis
- Proteolyses
- Protein Degradation
- Degradation, Protein
- Degradations, Protein
- Protein Degradations
Protein Digestion- Protein Digestion
- Digestion, Protein
- Digestions, Protein
- Protein Digestions
|
Below are MeSH descriptors whose meaning is more general than "Proteolysis".
Below are MeSH descriptors whose meaning is more specific than "Proteolysis".
This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 2 | 3 | 5 |
| 2012 | 2 | 3 | 5 |
| 2013 | 3 | 6 | 9 |
| 2014 | 10 | 13 | 23 |
| 2015 | 2 | 10 | 12 |
| 2016 | 1 | 7 | 8 |
| 2017 | 0 | 16 | 16 |
| 2018 | 1 | 6 | 7 |
| 2019 | 0 | 4 | 4 |
| 2020 | 6 | 9 | 15 |
| 2021 | 4 | 4 | 8 |
| 2022 | 0 | 2 | 2 |
| 2023 | 1 | 1 | 2 |
| 2024 | 0 | 5 | 5 |
| 2025 | 1 | 5 | 6 |
| 2026 | 1 | 5 | 6 |
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Below are the most recent publications written about "Proteolysis" by people in Profiles.
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Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation. Blood Cancer Discov. 2026 Nov 03; 7(6):978-998.
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FBXL21 regulates diurnal proteostasis in skeletal muscle by targeting DNAJB6 and client proteins. EMBO Rep. 2026 Nov; 27(21):6366-6395.
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Leveraging high-throughput proteomics and AI-based protein folding to accelerate VAV1 molecular glue discovery. Nat Commun. 2026 09 12; 17(1).
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Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders. J Med Chem. 2026 Aug 27; 69(16):19822-19840.
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Myeloid MMP14 couples extracellular proteolysis to inflammatory and metabolic remodeling during obesity. Cell Rep. 2026 Jul 28; 45(7):117681.
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Synthesis, structure-activity relationships, antitumor activities and mechanistic studies of ENL-degrading compounds. Eur J Med Chem. 2026 Oct 15; 316:118989.
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TFEB degradation is regulated by an IKK/?-TrCP2 phosphorylation-ubiquitination cascade. Nat Commun. 2026 Apr 01; 17(1).
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Rab4 spatially and functionally converges with Rab7 in the degradative endolysosomal network. Mol Biol Cell. 2026 Mar 01; 37(3):ar18.
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HiBiT-RR and nLucK0 Tagging Systems for Monitoring Targeted Protein Degradation. Methods Mol Biol. 2026; 3069:3-11.
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Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Science. 2026 Jan 08; 391(6781):195-201.