"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
| Descriptor ID |
D059748
|
| MeSH Number(s) |
G02.111.720 G03.812
|
| Concept/Terms |
Proteolysis- Proteolysis
- Proteolyses
- Protein Degradation
- Degradation, Protein
- Degradations, Protein
- Protein Degradations
Protein Digestion- Protein Digestion
- Digestion, Protein
- Digestions, Protein
- Protein Digestions
|
Below are MeSH descriptors whose meaning is more general than "Proteolysis".
Below are MeSH descriptors whose meaning is more specific than "Proteolysis".
This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 4 | 5 | 9 |
| 2012 | 3 | 13 | 16 |
| 2013 | 8 | 16 | 24 |
| 2014 | 9 | 19 | 28 |
| 2015 | 5 | 15 | 20 |
| 2016 | 0 | 13 | 13 |
| 2017 | 1 | 28 | 29 |
| 2018 | 1 | 8 | 9 |
| 2019 | 2 | 11 | 13 |
| 2020 | 9 | 16 | 25 |
| 2021 | 4 | 13 | 17 |
| 2022 | 0 | 4 | 4 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proteolysis" by people in Profiles.
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Degradation trumps mutations in cancer. Science. 2024 Feb 02; 383(6682):480-481.
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Cell jamming in a collagen-based interface assay is tuned by collagen density and proteolysis. J Cell Sci. 2023 12 01; 136(23).
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The rise of degrader drugs. Cell Chem Biol. 2023 08 17; 30(8):864-878.
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Regulation of Cyclin D1 Degradation by Ubiquitin-Specific Protease 27X Is Critical for Cancer Cell Proliferation and Tumor Growth. Mol Cancer Res. 2022 12 02; 20(12):1751-1762.
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Applications of covalent chemistry in targeted protein degradation. Chem Soc Rev. 2022 Nov 14; 51(22):9243-9261.
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The role of E3 ubiquitin ligase in multiple myeloma: potential for cereblon E3 ligase modulators in the treatment of relapsed/refractory disease. Expert Rev Proteomics. 2022 Apr-Jun; 19(4-6):235-246.
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Targeted Protein Degradation via Lysosomes. Biochemistry. 2023 02 07; 62(3):564-579.
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A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth. J Hematol Oncol. 2022 04 08; 15(1):41.
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021 11 25; 12(1):6896.
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Generation and Release of Neurogranin, Vimentin, and MBP Proteolytic Peptides, Following Traumatic Brain Injury. Mol Neurobiol. 2022 Feb; 59(2):731-747.