"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
| Descriptor ID |
D025801
|
| MeSH Number(s) |
D12.776.947.500
|
| Concept/Terms |
Ubiquitin- Ubiquitin
- ATP-Dependent Proteolysis Factor 1
- ATP Dependent Proteolysis Factor 1
- HMG-20
- APF-1
- High Mobility Protein 20
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".
This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 3 | 1 | 4 |
| 2003 | 2 | 2 | 4 |
| 2004 | 4 | 5 | 9 |
| 2005 | 7 | 7 | 14 |
| 2006 | 7 | 5 | 12 |
| 2007 | 6 | 3 | 9 |
| 2008 | 2 | 3 | 5 |
| 2009 | 3 | 1 | 4 |
| 2010 | 0 | 3 | 3 |
| 2011 | 1 | 3 | 4 |
| 2012 | 2 | 1 | 3 |
| 2013 | 3 | 4 | 7 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 3 | 3 | 6 |
| 2018 | 2 | 3 | 5 |
| 2019 | 1 | 1 | 2 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 4 | 5 |
| 2024 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Ubiquitin" by people in Profiles.
-
Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2024 Jul 09; 121(28):e2322972121.
-
Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases. Commun Biol. 2024 03 13; 7(1):321.
-
Ubiquitin-proteasome system regulation of a key gene regulatory factor, Paf1C. Gene. 2024 Feb 05; 894:148004.
-
A novel ubiquitin-proteasome system regulation of Sgf73/ataxin-7 that maintains the integrity of the coactivator SAGA in orchestrating transcription. Genetics. 2023 07 06; 224(3).
-
Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. Brain. 2023 03 01; 146(3):880-897.
-
Biallelic variants in HECT E3 paralogs, HECTD4 and?UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome. Genet Med. 2023 02; 25(2):100323.
-
The role of E3 ubiquitin ligase in multiple myeloma: potential for cereblon E3 ligase modulators in the treatment of relapsed/refractory disease. Expert Rev Proteomics. 2022 Apr-Jun; 19(4-6):235-246.
-
Targeted Protein Degradation via Lysosomes. Biochemistry. 2023 02 07; 62(3):564-579.
-
USP7 substrates identified by proteomics analysis reveal the specificity of USP7. Genes Dev. 2022 09 01; 36(17-18):1016-1030.
-
Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NF?B-mediated glial inflammation in a Drosophila model of human disease. Hum Mol Genet. 2022 08 25; 31(17):2857-2875.