"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
| Descriptor ID |
D025801
|
| MeSH Number(s) |
D12.776.947.500
|
| Concept/Terms |
Ubiquitin- Ubiquitin
- ATP-Dependent Proteolysis Factor 1
- ATP Dependent Proteolysis Factor 1
- HMG-20
- APF-1
- High Mobility Protein 20
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".
This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 3 | 1 | 4 |
| 2003 | 2 | 1 | 3 |
| 2004 | 2 | 6 | 8 |
| 2005 | 6 | 7 | 13 |
| 2006 | 7 | 4 | 11 |
| 2007 | 6 | 3 | 9 |
| 2008 | 2 | 3 | 5 |
| 2009 | 3 | 2 | 5 |
| 2010 | 1 | 3 | 4 |
| 2011 | 1 | 3 | 4 |
| 2012 | 2 | 1 | 3 |
| 2013 | 3 | 3 | 6 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 2 | 3 |
| 2016 | 0 | 2 | 2 |
| 2017 | 3 | 3 | 6 |
| 2018 | 3 | 2 | 5 |
| 2019 | 1 | 1 | 2 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 5 | 5 |
| 2024 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Ubiquitin" by people in Profiles.
-
Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases. Commun Biol. 2024 03 13; 7(1):321.
-
Biallelic variants in HECT E3 paralogs, HECTD4 and?UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome. Genet Med. 2023 02; 25(2):100323.
-
USP7 substrates identified by proteomics analysis reveal the specificity of USP7. Genes Dev. 2022 09 01; 36(17-18):1016-1030.
-
Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NF?B-mediated glial inflammation in a Drosophila model of human disease. Hum Mol Genet. 2022 08 25; 31(17):2857-2875.
-
The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. BMC Biol. 2022 07 13; 20(1):161.
-
p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Cancer Res. 2022 03 01; 82(5):916-928.
-
A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Cancer Res. 2021 09 01; 81(17):4441-4454.
-
Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and a-Synuclein, as Reported in ALS-PDC. J Neuropathol Exp Neurol. 2021 02 22; 80(3):286-288.
-
Elevated post-ischemic ubiquitination results from suppression of deubiquitinase activity and not proteasome inhibition. Cell Mol Life Sci. 2021 Mar; 78(5):2169-2183.
-
The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes. Sci Rep. 2020 08 18; 10(1):13942.