"Polyubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oligomer formed from the repetitive linking of the C-terminal glycine of one UBIQUITIN molecule via an isopeptide bond to a lysine residue on a second ubiquitin molecule. It is structurally distinct from UBIQUITIN C, which is a single protein containing a tandemly arrayed ubiquitin peptide sequence.
| Descriptor ID |
D025821
|
| MeSH Number(s) |
D12.776.947.500.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polyubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Polyubiquitin".
This graph shows the total number of publications written about "Polyubiquitin" by people in this website by year, and whether "Polyubiquitin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Polyubiquitin" by people in Profiles.
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UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN. J Biol Chem. 2017 10 06; 292(40):16539-16553.
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Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS Genet. 2016 05; 12(5):e1006054.
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Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers. Biochemistry. 2015 Jul 28; 54(29):4411-4.
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Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1942-1952.
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Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling. Sci Rep. 2013; 3:2344.
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Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFa-induced NF-?B activation via mediating TAK1 degradation. Cell Signal. 2012 Jul; 24(7):1381-9.
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RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. PLoS One. 2011; 6(9):e24367.
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Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells. Mol Cancer Ther. 2010 Aug; 9(8):2232-42.
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Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer. 2010 Feb 22; 9:42.
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NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 2009 Mar 15; 23(6):729-39.