Ubiquitin-Protein Ligases
"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
| Descriptor ID |
D044767
|
| MeSH Number(s) |
D08.811.464.938.750
|
| Concept/Terms |
Ubiquitin-Protein Ligases- Ubiquitin-Protein Ligases
- Ligases, Ubiquitin-Protein
- Ubiquitin Protein Ligases
- E3 Ubiquitin Ligase
- Ligase, E3 Ubiquitin
- Ubiquitin Ligase, E3
- Ubiquitin-Protein Ligase E3
- Ligase E3, Ubiquitin-Protein
- Ubiquitin Protein Ligase E3
- Ubiquitin Ligase E3
- Ligase E3, Ubiquitin
- Ubiquitin-Protein Ligase
- Ligase, Ubiquitin-Protein
- Ubiquitin Protein Ligase
- E3 Ligase
- Ligase, E3
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".
This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 2 | 6 | 8 |
| 1999 | 1 | 5 | 6 |
| 2000 | 1 | 2 | 3 |
| 2001 | 2 | 4 | 6 |
| 2002 | 0 | 3 | 3 |
| 2003 | 4 | 3 | 7 |
| 2004 | 4 | 6 | 10 |
| 2005 | 0 | 2 | 2 |
| 2006 | 6 | 2 | 8 |
| 2007 | 2 | 6 | 8 |
| 2008 | 3 | 3 | 6 |
| 2009 | 3 | 2 | 5 |
| 2010 | 7 | 5 | 12 |
| 2011 | 7 | 6 | 13 |
| 2012 | 2 | 3 | 5 |
| 2013 | 6 | 4 | 10 |
| 2014 | 10 | 5 | 15 |
| 2015 | 8 | 9 | 17 |
| 2016 | 8 | 5 | 13 |
| 2017 | 15 | 9 | 24 |
| 2018 | 5 | 7 | 12 |
| 2019 | 5 | 2 | 7 |
| 2020 | 6 | 2 | 8 |
| 2021 | 5 | 4 | 9 |
| 2022 | 4 | 8 | 12 |
| 2023 | 1 | 4 | 5 |
| 2024 | 2 | 6 | 8 |
| 2025 | 5 | 4 | 9 |
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Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.
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Increasing Paternal Age Associated With Elevated Risk of De Novo Mutations in Offspring Diagnosed With Sporadic Bilateral Retinoblastoma. Pediatr Blood Cancer. 2025 Oct; 72(10):e31936.
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The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial. Nat Med. 2025 Sep; 31(9):2936-2945.
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Molecular and clinical determinants of response to checkpoint inhibitor immunotherapy in glioblastoma. J Neurooncol. 2025 Oct; 175(1):453-461.
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MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation. ACS Chem Biol. 2025 Apr 18; 20(4):896-906.
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Unraveling the Molecular and Clinical Consequences of an Intragenic TRIP12 Duplication Using Genomic and RNA Analyses. Am J Med Genet A. 2025 Jul; 197(7):e64036.
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Androgen receptor ubiquitination links KCTD13 to genitourinary tract defects. FASEB J. 2025 Feb 28; 39(4):e70406.
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Characterization of RNF144B and PPP2R2A identified by a novel approach using TCGA data in ovarian cancer. Sci Rep. 2025 Feb 13; 15(1):5414.
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Sequence variants in HECTD1 result in a variable neurodevelopmental disorder. Am J Hum Genet. 2025 Mar 06; 112(3):537-553.
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Mutational and co-mutational landscape of early onset colorectal cancer. Biomarkers. 2025 Feb; 30(1):64-76.
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Sestrin2 balances mitophagy and apoptosis through the PINK1-Parkin pathway to attenuate severe acute pancreatitis. Cell Signal. 2025 Feb; 126:111518.