Ubiquitin-Protein Ligase Complexes
"Ubiquitin-Protein Ligase Complexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
| Descriptor ID |
D043743
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| MeSH Number(s) |
D08.811.464.938
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| Concept/Terms |
Ubiquitin-Protein Ligase Complexes- Ubiquitin-Protein Ligase Complexes
- Complexes, Ubiquitin-Protein Ligase
- Ligase Complexes, Ubiquitin-Protein
- Ubiquitin Protein Ligase Complexes
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligase Complexes".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligase Complexes".
This graph shows the total number of publications written about "Ubiquitin-Protein Ligase Complexes" by people in this website by year, and whether "Ubiquitin-Protein Ligase Complexes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ubiquitin-Protein Ligase Complexes" by people in Profiles.
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SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene. 2017 08 17; 36(33):4767-4777.
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Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15; 307(8):G777-92.
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Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle. 2012 May 15; 11(10):2030-8.
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Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Neuroscience. 2012 May 17; 210:308-32.
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Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell. 2011 Jan 21; 144(2):187-99.
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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009 Aug 15; 23(16):1910-28.
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The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles. J Biol Chem. 2005 Feb 04; 280(5):3920-7.
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Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol. 2004 Oct; 6(10):1003-9.
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Control of APC-Cdc20 by the tumor suppressor RASSF1A. Cell Cycle. 2004 May; 3(5):574-6.
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The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol. 2004 Feb; 6(2):129-37.