Ubiquitin-Activating Enzymes
"Ubiquitin-Activating Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and UBIQUITIN. It then transfers the activated ubiquitin to one of the UBIQUITIN-PROTEIN LIGASES.
| Descriptor ID |
D044764
|
| MeSH Number(s) |
D08.811.464.938.249
|
| Concept/Terms |
Ubiquitin-Activating Enzymes- Ubiquitin-Activating Enzymes
- Enzymes, Ubiquitin-Activating
- Ubiquitin Activating Enzymes
- Ubiquitination Activating Enzyme E1
- Ubiquitin-Activating Enzyme
- Enzyme, Ubiquitin-Activating
- Ubiquitin Activating Enzyme
- Ubiquitin-Activating Enzyme E1
- Enzyme E1, Ubiquitin-Activating
- Ubiquitin Activating Enzyme E1
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Activating Enzymes".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Activating Enzymes".
This graph shows the total number of publications written about "Ubiquitin-Activating Enzymes" by people in this website by year, and whether "Ubiquitin-Activating Enzymes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ubiquitin-Activating Enzymes" by people in Profiles.
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[VEXAS-like auto inflammatory syndrome: 2?cases]. Rev Med Interne. 2025 Mar; 46(3):139-145.
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UBA1 inhibition sensitizes cancer cells to PARP inhibitors. Cell Rep Med. 2024 Dec 17; 5(12):101834.
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Downregulation of UBA1 expression in myelodysplastic neoplasm. Leukemia. 2024 Oct; 38(10):2284-2288.
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VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic): clinical review in a rapidly emerging field. Leuk Lymphoma. 2024 Sep; 65(9):1245-1257.
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Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays. Elife. 2023 Dec 11; 12.
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GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism. Redox Biol. 2022 10; 56:102458.
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Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons. JAMA Psychiatry. 2020 11 01; 77(11):1172-1180.
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Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma. Blood. 2019 04 04; 133(14):1572-1584.
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The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells. J Hematol Oncol. 2018 05 31; 11(1):74.
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Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure. 2017 07 05; 25(7):1120-1129.e3.