Ubiquitin-Activating Enzymes
"Ubiquitin-Activating Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and UBIQUITIN. It then transfers the activated ubiquitin to one of the UBIQUITIN-PROTEIN LIGASES.
Descriptor ID |
D044764
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MeSH Number(s) |
D08.811.464.938.249
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Concept/Terms |
Ubiquitin-Activating Enzymes- Ubiquitin-Activating Enzymes
- Enzymes, Ubiquitin-Activating
- Ubiquitin Activating Enzymes
- Ubiquitination Activating Enzyme E1
- Ubiquitin-Activating Enzyme
- Enzyme, Ubiquitin-Activating
- Ubiquitin Activating Enzyme
- Ubiquitin-Activating Enzyme E1
- Enzyme E1, Ubiquitin-Activating
- Ubiquitin Activating Enzyme E1
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Activating Enzymes".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Activating Enzymes".
This graph shows the total number of publications written about "Ubiquitin-Activating Enzymes" by people in this website by year, and whether "Ubiquitin-Activating Enzymes" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 |
2003 | 1 | 0 | 1 |
2004 | 3 | 2 | 5 |
2005 | 0 | 1 | 1 |
2006 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
2008 | 2 | 0 | 2 |
2009 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2011 | 1 | 1 | 2 |
2013 | 3 | 2 | 5 |
2014 | 1 | 1 | 2 |
2015 | 0 | 1 | 1 |
2016 | 0 | 1 | 1 |
2017 | 2 | 0 | 2 |
2018 | 0 | 1 | 1 |
2019 | 1 | 0 | 1 |
2022 | 0 | 1 | 1 |
2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ubiquitin-Activating Enzymes" by people in Profiles.
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Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays. Elife. 2023 Dec 11; 12.
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GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism. Redox Biol. 2022 10; 56:102458.
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Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons. JAMA Psychiatry. 2020 11 01; 77(11):1172-1180.
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Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma. Blood. 2019 04 04; 133(14):1572-1584.
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The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells. J Hematol Oncol. 2018 05 31; 11(1):74.
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Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure. 2017 07 05; 25(7):1120-1129.e3.
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Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis. Mol Cancer Ther. 2017 08; 16(8):1693-1704.
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Autophagy machinery impaired interferon signalling pathways to benefit hepatitis B virus replication. Asian Pac J Allergy Immunol. 2016 Mar; 34(1):77-85.
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FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4. Mol Cell. 2016 Feb 04; 61(3):419-433.
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A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. PLoS One. 2015; 10(4):e0122628.