E2F1 Transcription Factor
"E2F1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.
| Descriptor ID |
D050687
|
| MeSH Number(s) |
D12.644.360.024.328.049 D12.776.157.057.158.049 D12.776.476.024.420.049 D12.776.660.769.049 D12.776.930.211.500
|
| Concept/Terms |
E2F1 Transcription Factor- E2F1 Transcription Factor
- Transcription Factor, E2F1
- Transcription Factor E2F-1
- Transcription Factor E2F 1
- E2F Transcription Factor 1 Protein
- Retinoblastoma-Associated Protein 1
- Retinoblastoma Associated Protein 1
- Retinoblastoma Binding Protein 3
- E2F-1 Transcription Factor
- Transcription Factor, E2F-1
- Transcription Factor E2F1
|
Below are MeSH descriptors whose meaning is more general than "E2F1 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "E2F1 Transcription Factor".
This graph shows the total number of publications written about "E2F1 Transcription Factor" by people in this website by year, and whether "E2F1 Transcription Factor" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 4 | 4 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 6 | 6 |
| 1999 | 0 | 8 | 8 |
| 2000 | 0 | 6 | 6 |
| 2001 | 0 | 9 | 9 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 5 | 5 |
| 2004 | 0 | 5 | 5 |
| 2005 | 2 | 1 | 3 |
| 2006 | 7 | 2 | 9 |
| 2007 | 5 | 2 | 7 |
| 2008 | 4 | 1 | 5 |
| 2009 | 1 | 1 | 2 |
| 2010 | 6 | 2 | 8 |
| 2011 | 2 | 1 | 3 |
| 2012 | 4 | 1 | 5 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 3 | 4 |
| 2015 | 1 | 0 | 1 |
| 2016 | 4 | 0 | 4 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "E2F1 Transcription Factor" by people in Profiles.
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E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling. Development. 2021 01 13; 148(1).
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The E2F1 transcription factor and RB tumor suppressor moonlight as DNA repair factors. Cell Cycle. 2020 09; 19(18):2260-2269.
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E2F1 sumoylation as a protective cellular mechanism in oxidative stress response. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):14958-14969.
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E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. Nat Commun. 2019 10 30; 10(1):4951.
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PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2019 11 15; 25(22):6839-6851.
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Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma. Cell Rep. 2018 12 26; 25(13):3693-3705.e6.
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Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. 2018 04 05; 173(2):499-514.e23.
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A functional variant at the miRNA binding site in E2F1 gene is associated with risk and tumor HPV16 status of oropharynx squamous cell carcinoma. Mol Carcinog. 2017 03; 56(3):1100-1106.
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A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer. Oncotarget. 2016 09 13; 7(42):68012-68022.
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Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro. Circ Res. 2016 Sep 02; 119(6):731-50.