Tumor Suppressor Protein p53
"Tumor Suppressor Protein p53" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
| Descriptor ID |
D016159
|
| MeSH Number(s) |
D12.776.157.687.650 D12.776.260.820 D12.776.624.776.775 D12.776.660.720.650 D12.776.744.845
|
| Concept/Terms |
Tumor Suppressor Protein p53- Tumor Suppressor Protein p53
- p53 Antigen
- TP53 Protein
- TRP53 Protein
- p53 Tumor Suppressor Protein
- pp53 Phosphoprotein
- Phosphoprotein, pp53
- Cellular Tumor Antigen p53
- Oncoprotein p53
|
Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p53".
Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor Protein p53".
This graph shows the total number of publications written about "Tumor Suppressor Protein p53" by people in this website by year, and whether "Tumor Suppressor Protein p53" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 6 | 1 | 7 |
| 1997 | 3 | 4 | 7 |
| 1998 | 2 | 7 | 9 |
| 1999 | 7 | 2 | 9 |
| 2000 | 9 | 7 | 16 |
| 2001 | 6 | 4 | 10 |
| 2002 | 7 | 4 | 11 |
| 2003 | 15 | 7 | 22 |
| 2004 | 9 | 7 | 16 |
| 2005 | 7 | 6 | 13 |
| 2006 | 5 | 5 | 10 |
| 2007 | 7 | 3 | 10 |
| 2008 | 3 | 5 | 8 |
| 2009 | 11 | 11 | 22 |
| 2010 | 13 | 5 | 18 |
| 2011 | 15 | 12 | 27 |
| 2012 | 8 | 11 | 19 |
| 2013 | 8 | 16 | 24 |
| 2014 | 16 | 8 | 24 |
| 2015 | 16 | 17 | 33 |
| 2016 | 11 | 14 | 25 |
| 2017 | 10 | 5 | 15 |
| 2018 | 15 | 6 | 21 |
| 2019 | 15 | 13 | 28 |
| 2020 | 7 | 9 | 16 |
| 2021 | 11 | 5 | 16 |
| 2022 | 3 | 11 | 14 |
| 2023 | 5 | 5 | 10 |
| 2024 | 2 | 6 | 8 |
| 2025 | 7 | 10 | 17 |
| 2026 | 4 | 4 | 8 |
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Below are the most recent publications written about "Tumor Suppressor Protein p53" by people in Profiles.
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Mutant p53 variants differentially impact replication initiation and activate cGAS-STING to affect immune checkpoint inhibition. Commun Biol. 2025 Nov 05; 8(1):1522.
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Clonal hematopoiesis and subsequent venous thromboembolism among survivors of autologous transplantation for lymphoma. J Natl Cancer Inst. 2025 Nov 01; 117(11):2394-2398.
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Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres. Cells. 2025 01 07; 14(2).
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Vaccines targeting p53 mutants elicit anti-tumor immunity. Cancer Lett. 2025 Feb 28; 611:217421.
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Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant. J Hematol Oncol. 2024 06 18; 17(1):45.
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Clonal Hematopoiesis and Therapy-Related Myeloid Neoplasms After Autologous Transplant for Hodgkin Lymphoma. J Clin Oncol. 2024 07 10; 42(20):2415-2424.
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A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors. Proc Natl Acad Sci U S A. 2023 10 31; 120(44):e2307793120.
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DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023 10 16; 3(10):2096-2112.
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The targeted next-generation sequence revealed SMAD4, AKT1, and TP53 mutations from circulating cell-free DNA of breast cancer and its effect on protein structure - A computational approach. J Biomol Struct Dyn. 2023; 41(24):15584-15597.
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An integrated investigation of structural and pathway alteration caused by PIK3CA and TP53 mutations identified in cfDNA of metastatic breast cancer. J Cell Biochem. 2023 02; 124(2):188-204.