"Patched Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of 12-pass transmembrane proteins originally identified in Drosophila that are receptors for HEDGEHOG PROTEINS. They have important roles in regulating CELL PROLIFERATION; CELL DIFFERENTIAION; and BODY PATTERNING and may also function as TUMOR SUPPRESSOR PROTEINS.
| Descriptor ID |
D000072079
|
| MeSH Number(s) |
D12.776.543.750.058 D12.776.624.776.633
|
| Concept/Terms |
Patched Receptors- Patched Receptors
- Receptors, Patched
- Patched Sonic Hedgehog Receptors
- Patched Receptor
- Receptor, Patched
- Patched Protein
|
Below are MeSH descriptors whose meaning is more general than "Patched Receptors".
Below are MeSH descriptors whose meaning is more specific than "Patched Receptors".
This graph shows the total number of publications written about "Patched Receptors" by people in this website by year, and whether "Patched Receptors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 5 | 5 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Patched Receptors" by people in Profiles.
-
Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling. Nat Cell Biol. 2017 May; 19(5):550-557.
-
Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level. Oncotarget. 2015 Jan 20; 6(2):1190-201.
-
Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell. 2014 Jul 14; 26(1):33-47.
-
Dynamic Hedgehog signalling pathway activity in germline stem cells. Andrology. 2014 Mar; 2(2):267-74.
-
Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma. Pediatr Blood Cancer. 2012 Jun; 58(6):1006-7.
-
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell. 2011 Feb 15; 19(2):177-91.
-
Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling. Int J Biochem Cell Biol. 2010 Sep; 42(9):1462-71.
-
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009 Aug 15; 23(16):1910-28.
-
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer. 2009 Aug; 53(2):136-44.
-
Stromal progesterone receptors mediate induction of Indian Hedgehog (IHH) in uterine epithelium and its downstream targets in uterine stroma. Endocrinology. 2009 Aug; 150(8):3871-6.