"Patched Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of 12-pass transmembrane proteins originally identified in Drosophila that are receptors for HEDGEHOG PROTEINS. They have important roles in regulating CELL PROLIFERATION; CELL DIFFERENTIAION; and BODY PATTERNING and may also function as TUMOR SUPPRESSOR PROTEINS.
| Descriptor ID |
D000072079
|
| MeSH Number(s) |
D12.776.543.750.058 D12.776.624.776.633
|
| Concept/Terms |
Patched Receptors- Patched Receptors
- Receptors, Patched
- Patched Sonic Hedgehog Receptors
- Patched Receptor
- Receptor, Patched
- Patched Protein
|
Below are MeSH descriptors whose meaning is more general than "Patched Receptors".
Below are MeSH descriptors whose meaning is more specific than "Patched Receptors".
This graph shows the total number of publications written about "Patched Receptors" by people in this website by year, and whether "Patched Receptors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 5 | 5 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 3 | 3 |
| 2014 | 0 | 4 | 4 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Patched Receptors" by people in Profiles.
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Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling. Nat Cell Biol. 2017 May; 19(5):550-557.
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Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma. Cancer Cell. 2015 Mar 09; 27(3):327-41.
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Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level. Oncotarget. 2015 Jan 20; 6(2):1190-201.
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PTCH1 expression at diagnosis predicts imatinib failure in chronic myeloid leukaemia patients in chronic phase. Am J Hematol. 2015 Jan; 90(1):20-6.
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The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors. Dev Cell. 2014 Oct 13; 31(1):34-47.
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Patched targeting peptides for imaging and treatment of hedgehog positive breast tumors. Biomed Res Int. 2014; 2014:525680.
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Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors. Dev Cell. 2014 Jun 23; 29(6):649-61.
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Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell. 2014 Jul 14; 26(1):33-47.
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 2014 Mar 17; 25(3):393-405.
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Dynamic Hedgehog signalling pathway activity in germline stem cells. Andrology. 2014 Mar; 2(2):267-74.