"Neuropilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
| Descriptor ID |
D039921
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| MeSH Number(s) |
D12.776.543.750.590
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Neuropilins".
Below are MeSH descriptors whose meaning is more specific than "Neuropilins".
This graph shows the total number of publications written about "Neuropilins" by people in this website by year, and whether "Neuropilins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 0 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 2 | 0 | 2 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Neuropilins" by people in Profiles.
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The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. Am J Physiol Heart Circ Physiol. 2016 05 01; 310(9):H1184-93.
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Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest. 2013 Dec; 123(12):5082-97.
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Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis. Clin Cancer Res. 2009 Nov 15; 15(22):6763-70.
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The role of neuropilins in cancer. Mol Cancer Ther. 2006 May; 5(5):1099-107.
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Neuropilins in neoplasms: expression, regulation, and function. Exp Cell Res. 2006 Mar 10; 312(5):584-93.
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C-reactive protein decreases expression of VEGF receptors and neuropilins and inhibits VEGF165-induced cell proliferation in human endothelial cells. Biochem Biophys Res Commun. 2005 Aug 05; 333(3):1003-10.
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Roles of neuropilins in neuronal development, angiogenesis, and cancers. World J Surg. 2005 Mar; 29(3):271-5.
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Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells. J Surg Res. 2004 Dec; 122(2):249-55.
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Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors. Cancer. 2004 Nov 15; 101(10):2341-50.