"Neuropilin-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
| Descriptor ID |
D039943
|
| MeSH Number(s) |
D12.776.543.750.590.750
|
| Concept/Terms |
Neuropilin-2- Neuropilin-2
- Neuropilin 2
- NRP2 Protein
- Npn-2 Protein
- Npn 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Neuropilin-2".
Below are MeSH descriptors whose meaning is more specific than "Neuropilin-2".
This graph shows the total number of publications written about "Neuropilin-2" by people in this website by year, and whether "Neuropilin-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2008 | 3 | 1 | 4 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Neuropilin-2" by people in Profiles.
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VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk. Oncogene. 2021 02; 40(5):964-979.
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COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development. 2012 May; 139(9):1630-9.
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Neuropilin-2 mediated ?-catenin signaling and survival in human gastro-intestinal cancer cell lines. PLoS One. 2011; 6(10):e23208.
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Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. J Clin Invest. 2010 May; 120(5):1694-707.
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Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma. Clin Cancer Res. 2008 Dec 15; 14(24):8052-60.
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Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies. Cancer J. 2008 May-Jun; 14(3):170-7.
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Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. Cancer Sci. 2008 Apr; 99(4):733-7.
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Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst. 2008 Jan 16; 100(2):109-20.
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Vascular endothelial growth factor receptors: expression and function in solid tumors. Clin Adv Hematol Oncol. 2004 Jan; 2(1):37-45.