"Receptors, Death Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
| Descriptor ID |
D053218
|
| MeSH Number(s) |
D12.776.543.750.690
|
| Concept/Terms |
Receptors, Death Domain- Receptors, Death Domain
- Death Receptors
- Death Domain Receptors
- Receptors, Death Domain Family
- Receptors, DR Family
- DR Family Receptors
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Death Domain".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Death Domain".
This graph shows the total number of publications written about "Receptors, Death Domain" by people in this website by year, and whether "Receptors, Death Domain" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Death Domain" by people in Profiles.
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Randomized Phase III Trial Evaluating Spartalizumab Plus Dabrafenib and Trametinib for BRAF V600-Mutant Unresectable or Metastatic Melanoma. J Clin Oncol. 2022 05 01; 40(13):1428-1438.
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Neratinib kills B-RAF V600E melanoma via ROS-dependent autophagosome formation and death receptor signaling. Pigment Cell Melanoma Res. 2022 01; 35(1):66-77.
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Not So FASt: Tumor Cells Resisting Death Drive CAR T-cell Dysfunction. Cancer Discov. 2020 04; 10(4):492-494.
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Targeting the apoptotic pathway in chondrosarcoma using recombinant human Apo2L/TRAIL (dulanermin), a dual proapoptotic receptor (DR4/DR5) agonist. Mol Cancer Ther. 2012 Nov; 11(11):2541-6.
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Stimulation of autophagy by autoantibody-mediated activation of death receptor cascades. Autophagy. 2008 Jul; 4(5):715-6.
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Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells. Mol Cancer Ther. 2007 Nov; 6(11):2967-75.
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Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells. Biochem Biophys Res Commun. 2007 Apr 20; 355(4):993-9.