"DCC Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.
| Descriptor ID |
D000075389
|
| MeSH Number(s) |
D12.644.360.075.413 D12.776.476.075.413 D12.776.543.750.003.500 D12.776.624.776.021
|
| Concept/Terms |
DCC Receptor- DCC Receptor
- Receptor, DCC
- DCC Tumor Suppressor Protein
- Deleted in Colorectal Carcinoma Protein
- DCC-Netrin-1 Receptor
- DCC Netrin 1 Receptor
- Receptor, DCC-Netrin-1
|
Below are MeSH descriptors whose meaning is more general than "DCC Receptor".
Below are MeSH descriptors whose meaning is more specific than "DCC Receptor".
This graph shows the total number of publications written about "DCC Receptor" by people in this website by year, and whether "DCC Receptor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "DCC Receptor" by people in Profiles.
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Downregulation of DCC sensitizes multiple myeloma cells to bortezomib treatment. Mol Med Rep. 2019 Jun; 19(6):5023-5029.
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A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration. Hypertension. 2016 09; 68(3):621-9.
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Identifying gene disruptions in novel balanced de novo constitutional translocations in childhood cancer patients by whole-genome sequencing. Genet Med. 2015 Oct; 17(10):831-5.
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Predictive and prognostic markers in colorectal cancer. Curr Oncol Rep. 2011 Jun; 13(3):206-15.
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ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol. 2006 Nov 20; 24(33):5313-27.
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Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. J Neurochem. 2005 Oct; 95(1):1-8.
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Status of deleted in colorectal cancer gene expression correlates with neuroblastoma metastasis. Lab Invest. 1998 Jun; 78(6):669-75.
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Presence of multiple incontiguous deleted regions at the long arm of chromosome 18 in head and neck cancer. Clin Cancer Res. 1998 Mar; 4(3):539-44.
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Decreased expression of the deleted in colorectal carcinoma gene in non-Hodgkin's lymphoma. Blood. 1995 May 15; 85(10):2813-6.