"Beclin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
| Descriptor ID |
D000071186
|
| MeSH Number(s) |
D12.644.360.075.335 D12.776.094.500 D12.776.476.075.335
|
| Concept/Terms |
Beclin-1- Beclin-1
- Beclin 1
- Beclin-1 Protein
- Beclin 1 Protein
- GT197 Protein
- ATG-6 Protein
- ATG 6 Protein
- Coiled-coil Myosin-like Bcl2-interacting Protein
- Coiled coil Myosin like Bcl2 interacting Protein
- Beclin1
- ATG6 Protein
|
Below are MeSH descriptors whose meaning is more general than "Beclin-1".
Below are MeSH descriptors whose meaning is more specific than "Beclin-1".
This graph shows the total number of publications written about "Beclin-1" by people in this website by year, and whether "Beclin-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
| 2023 | 0 | 4 | 4 |
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Below are the most recent publications written about "Beclin-1" by people in Profiles.
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THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway. Int J Mol Sci. 2024 Feb 10; 25(4).
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GSK-3? as a Potential Coordinator of Anabolic and Catabolic Pathways in Hepatitis C Virus Insulin Resistance. Intervirology. 2024; 67(1):6-18.
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Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer. Autophagy. 2024 01; 20(1):114-130.
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Autophagy is required for stem-cell-mediated endometrial programming and the establishment of pregnancy. Autophagy. 2024 04; 20(4):970-972.
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Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production. Cell Rep. 2023 07 25; 42(7):112708.
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Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy. Dev Cell. 2023 05 22; 58(10):885-897.e4.
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TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study. BMC Cancer. 2021 Oct 18; 21(1):1118.
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Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration. Cell Death Dis. 2021 07 02; 12(7):664.
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Thymoquinone Inhibits Proliferation and Migration of MDA-MB-231 Triple Negative Breast Cancer Cells by Suppressing Autophagy, Beclin-1 and LC3. Anticancer Agents Med Chem. 2021; 21(3):355-364.
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TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKK?/VPS34 pathway. Nat Commun. 2019 12 10; 10(1):5630.