"Sequestosome-1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
| Descriptor ID |
D000071456
|
| MeSH Number(s) |
D12.644.360.024.329 D12.776.094.750 D12.776.157.057.160 D12.776.476.024.422
|
| Concept/Terms |
Sequestosome-1 Protein- Sequestosome-1 Protein
- Sequestosome 1 Protein
- Ubiquitin-Binding Protein p62
- Ubiquitin Binding Protein p62
- Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
- Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
- EBI3-Associated Protein of 60 KDa
- EBI3 Associated Protein of 60 KDa
- EBIAP Protein
|
Below are MeSH descriptors whose meaning is more general than "Sequestosome-1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Sequestosome-1 Protein".
This graph shows the total number of publications written about "Sequestosome-1 Protein" by people in this website by year, and whether "Sequestosome-1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sequestosome-1 Protein" by people in Profiles.
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The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. 2019 04; 15(4):583-598.
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Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik. Mol Cell Biol. 2014 Sep 15; 34(18):3435-49.
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Autophagy mediates HIF2a degradation and suppresses renal tumorigenesis. Oncogene. 2015 May 07; 34(19):2450-60.
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Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling. Sci Signal. 2013 Oct 01; 6(295):ra86.
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Autophagy in idiopathic pulmonary fibrosis. PLoS One. 2012; 7(7):e41394.
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Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J Biol Chem. 2012 Jun 01; 287(23):19687-98.
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KrasG12D-induced IKK2/?/NF-?B activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Jan 17; 21(1):105-20.
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RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. PLoS One. 2011; 6(9):e24367.
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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010 Jul; 30(13):3275-85.