"Paxillin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.
| Descriptor ID |
D051419
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| MeSH Number(s) |
D12.644.360.024.316 D12.776.157.057.092 D12.776.476.024.397 D12.776.512.374 D12.776.744.665
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Paxillin".
Below are MeSH descriptors whose meaning is more specific than "Paxillin".
This graph shows the total number of publications written about "Paxillin" by people in this website by year, and whether "Paxillin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Paxillin" by people in Profiles.
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The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis. Oncogene. 2021 01; 40(2):384-395.
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Relief of talin autoinhibition triggers a force-independent association with vinculin. J Cell Biol. 2020 01 06; 219(1).
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CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia. J Immunol. 2015 Dec 01; 195(11):5380-92.
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Paxillin is the target of c-Jun N-terminal kinase in Schwann cells and regulates migration. Cell Signal. 2012 Nov; 24(11):2061-9.
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EGF-like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement. Endocrinology. 2012 Aug; 153(8):3949-59.
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Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G601-11.
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Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6. J Biol Chem. 2010 Jul 30; 285(31):24270-81.
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Paradoxical roles of FAK in tumor cell migration and metastasis. Cell Cycle. 2009 Nov 01; 8(21):3474-9.
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Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer. Cancer Res. 2008 Jul 15; 68(14):5839-48.
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Neurofibromatosis 2 tumor suppressor, the gene induced by valproic acid, mediates neurite outgrowth through interaction with paxillin. Exp Cell Res. 2008 Jul 01; 314(11-12):2279-88.