"BRCA1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
| Descriptor ID |
D019313
|
| MeSH Number(s) |
D12.776.313.125 D12.776.624.776.100 D12.776.660.100 D12.776.744.100 D12.776.930.137
|
| Concept/Terms |
BRCA1 Protein- BRCA1 Protein
- Breast Cancer Type 1 Susceptibility Protein
- Breast Cancer 1 Protein
- Ring Finger Protein 53
- BRCA1 Gene Product
- Breast Cancer 1 Gene Product
|
Below are MeSH descriptors whose meaning is more general than "BRCA1 Protein".
Below are MeSH descriptors whose meaning is more specific than "BRCA1 Protein".
This graph shows the total number of publications written about "BRCA1 Protein" by people in this website by year, and whether "BRCA1 Protein" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 |
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 5 | 5 |
| 1997 | 4 | 0 | 4 |
| 1998 | 2 | 2 | 4 |
| 1999 | 3 | 1 | 4 |
| 2000 | 5 | 0 | 5 |
| 2001 | 4 | 0 | 4 |
| 2002 | 8 | 1 | 9 |
| 2003 | 8 | 4 | 12 |
| 2004 | 5 | 3 | 8 |
| 2005 | 3 | 1 | 4 |
| 2006 | 3 | 1 | 4 |
| 2007 | 5 | 4 | 9 |
| 2008 | 3 | 2 | 5 |
| 2009 | 10 | 3 | 13 |
| 2010 | 4 | 4 | 8 |
| 2011 | 3 | 5 | 8 |
| 2012 | 3 | 10 | 13 |
| 2013 | 8 | 2 | 10 |
| 2014 | 9 | 4 | 13 |
| 2015 | 6 | 6 | 12 |
| 2016 | 4 | 9 | 13 |
| 2017 | 9 | 6 | 15 |
| 2018 | 9 | 7 | 16 |
| 2019 | 7 | 11 | 18 |
| 2020 | 3 | 10 | 13 |
| 2021 | 3 | 15 | 18 |
| 2022 | 5 | 9 | 14 |
| 2023 | 5 | 8 | 13 |
| 2024 | 4 | 10 | 14 |
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Below are the most recent publications written about "BRCA1 Protein" by people in Profiles.
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BRCA-mutated breast cancer: the unmet need, challenges and therapeutic benefits of genetic testing. Br J Cancer. 2024 Nov; 131(9):1400-1414.
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Strategies for the prevention or reversal of PARP inhibitor resistance. Expert Rev Anticancer Ther. 2024 Oct; 24(10):959-975.
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BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov. 2024 Aug 02; 14(8):1476-1495.
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Pharmacodynamic Activity of [18F]-Fluorthanatrace Poly(ADP-ribose) Polymerase Positron Emission Tomography in Patients With BRCA1/2-Mutated Breast Cancer Receiving Talazoparib. JCO Precis Oncol. 2024 Aug; 8:e2400303.
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Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial. Oncologist. 2024 Jul 05; 29(7):638-e952.
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Neoadjuvant talazoparib in patients with germline BRCA1/2 mutation-positive, early-stage triple-negative breast cancer: exploration of tumor BRCA mutational status. Breast Cancer. 2024 Sep; 31(5):886-897.
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Clinical Outcomes for BRCA Pathogenic Variant Carriers With Breast Cancer Undergoing Breast Conservation. JAMA Netw Open. 2024 Jun 03; 7(6):e2418486.
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Homologous recombination deficiency should be tested for in patients with advanced stage high-grade serous ovarian cancer aged 70?years and over. Gynecol Oncol. 2024 08; 187:221-226.
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Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families reveals complex genetic architecture and phenocopies. HGG Adv. 2024 Jul 18; 5(3):100306.
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Hereditary Breast Cancer: BRCA Mutations and Beyond. Radiol Clin North Am. 2024 Jul; 62(4):627-642.