"Ataxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.
| Descriptor ID |
D000067528
|
| MeSH Number(s) |
D12.776.631.069 D12.776.660.075
|
| Concept/Terms |
Ataxins- Ataxins
- Spinocerebellar Ataxia Proteins
- Ataxia Proteins, Spinocerebellar
- Proteins, Spinocerebellar Ataxia
- Ataxin Proteins
- Proteins, Ataxin
|
Below are MeSH descriptors whose meaning is more general than "Ataxins".
Below are MeSH descriptors whose meaning is more specific than "Ataxins".
This graph shows the total number of publications written about "Ataxins" by people in this website by year, and whether "Ataxins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 5 | 5 |
| 1998 | 0 | 5 | 5 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 6 | 6 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 5 | 5 |
| 2005 | 0 | 4 | 4 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 6 | 6 |
| 2008 | 0 | 6 | 6 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 5 | 5 |
| 2013 | 0 | 5 | 5 |
| 2015 | 0 | 1 | 1 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ataxins" by people in Profiles.
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Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1. J Clin Invest. 2026 06 15; 136(12).
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Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. Cell. 2015 Mar 12; 160(6):1087-98.
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Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. J Neurosci. 2013 May 29; 33(22):9328-36.
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RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 2013 Jun 20; 498(7454):325-331.
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Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery. PLoS Genet. 2013 Mar; 9(3):e1003359.
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Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum. J Neurosci. 2013 Mar 27; 33(13):5806-20.
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Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua. Genes Dev. 2013 Mar 15; 27(6):590-5.
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Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua. Science. 2011 Nov 04; 334(6056):690-3.
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ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell. 2011 Oct 18; 21(4):746-57.
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Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1. Hum Mol Genet. 2011 Dec 15; 20(24):4822-30.